FlyBase Allele Report: Dmel\gsb-n[hs.PZ]

General Information

Symbol

Dmel\gsb-n^hs.PZ

Species

D. melanogaster

Name

heat shock construct of Zhang

FlyBase ID

FBal0039382

Feature type

allele

Associated gene

Dmel\gsb-n

Associated Insertion(s)

Carried in Construct

P{hs-gsbp}

Key Links

Transgenic product class

cDNA

(Zhang et al., 1994)

wild_type

(Zhang et al., 1994)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Zhang et al., 1994)

wild_type

(Zhang et al., 1994)

Mutagen

in vitro construct

(Zhang et al., 1994)

Progenitor genotype

Carried in construct

P{hs-gsbp}

Cytology

Description

cDNA containing entire coding region of gsb-n, driven by an Hsp70 promoter.

(Zhang et al., 1994)

Allele components

Component

Use(s)

Regulatory region(s)

Hsp70

Encoded product / tool

gsb-n

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

wild-type

(Zhang et al., 1994)

Phenotype Manifest In

embryonic epidermis

(Zhang et al., 1994)

Keilin organ

(Zhang et al., 1994)

larval DA1 motor neuron

(Zhang et al., 1994)

larval EL neuron

(Zhang et al., 1994)

larval RP2 motor neuron

(Zhang et al., 1994)

pCC neuron

(Zhang et al., 1994)

U neuron

(Zhang et al., 1994)

Detailed Description

Statement

Reference

Groups of denticles or entire denticle belts are replaced with naked cuticle. Heat shocks from 2.75 to 3.25 hours transform complete segments while those after 4 hours transform parts of segments. Multiple heat shocks generate embryos with completely naked cuticles. Ectopic Keilin's organs sometimes develop. The CNS also shows fusion of two commissures in each segment and the elimination of the longitudinal connectives. RP2 neurons and EL neurons are eliminated in most segments and aCC and pCC are eliminated in some segments. CQ neurons are duplicated in some segments.

(Zhang et al., 1994)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

gsb-n^hs.PZ rescues Df(2R)gsb

(Zhang et al., 1994)

Comments

A series of three heat shocks almost completely rescues the mutant Df(2R)gsb cuticle phenotype.

(Zhang et al., 1994)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

gsb-n^hs.PZ

gsb-p^hs.PZ

(Zhang et al., 1994)

Name Synonyms

heat shock construct of Zhang

(Zhang et al., 1994)

Secondary FlyBase IDs

References (1)

Report Sections

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