FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\her3
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General Information
Symbol
Dmel\her3
Species
D. melanogaster
Name
FlyBase ID
FBal0039401
Feature type
allele
Associated gene
Dmel\her
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Pultz et al., 1994)
Mutagen
X ray
(Pultz et al., 1994)
Progenitor genotype
Caused by aberration
Ab(2L;?)her3
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Heat induced expression of herhs.PL fully rescues male and female lethality. Male and female her3/her8 transheterozygotes are lethal, her1/her3 transheterozygotes fail to show defects in the Muscle of Lawrence.

      (Li and Baker, 1998)

      Homozygous females are transformed to intersexes under restrictive and semi-restrictive temperatures (29oC and 25oC). Mutant males show a weak transformation to intersexuality in the sixth sternite has bristles. Surviving daughters of homozygotes and transheterozygotes raised at semi-restrictive temperatures show a high frequency of morphological defects not seen in sons. Maternal effect female lethality is enhanced by Sxlf1. Severely restrictive conditions (29oC for more than 2 days) reveals maternal sex-nonspecific lethality for all heteroallelic combinations except her3/her2 : embryos show defect in gastrulation and differentiation of the cuticles.

      (Pultz et al., 1994)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      her3 is rescued by her+t17

      (Li and Baker, 1998)

      her3 is rescued by her+t10

      (Li and Baker, 1998)

      her3 is rescued by herhs.PL

      (Li and Baker, 1998)
      Comments

      Heat induced expression of herhs.PL fully rescues lethality.

      (Li and Baker, 1998)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Relative severity of the effects on female and male sexual differentiation is her3 > her1 > her2 > hermat-1. Relative severity of the effects on viability is her3 > her1 = her2 > hermat-1.

      (Pultz et al., 1994)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      her3
      Name Synonyms
      Secondary FlyBase IDs
        References (3)