FlyBase Allele Report: Dmel\orb[dec]

General Information

Symbol

Dmel\orb^dec

Species

D. melanogaster

Name

degenerating cysts

FlyBase ID

FBal0039709

Feature type

allele

Associated gene

Dmel\orb

Associated Insertion(s)

P{PZ}orb^dec

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - genetic evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Christerson and McKearin, 1994, Lantz et al., 1994)

Mutagen

P-element activity

(Christerson and McKearin, 1994, Lantz et al., 1994)

Progenitor genotype

Associated Insertion(s)

P{PZ}orb^dec

Cytology

Description

P-element insertion in the 5' untranslated region (UTR) of the female orb transcript between position +499 and +500 nucleotides.

(Christerson and McKearin, 1994)

P-element insertion in one of the exons encoding the 5' leader sequence of the female orb mRNA, upstream of all known male-specific exons.

(Lantz et al., 1994)

Allele components

Component

Use(s)

Inserted element

P{PZ}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3R:23,279,359..23,279,359 [-]

(Barr et al., 2019, Spradling et al., 1999, BDGP Project Members, 1994-1999, Christerson and McKearin, 1994, Lantz et al., 1994)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female sterile

(Christerson and McKearin, 1994, Lantz et al., 1994)

female sterile | recessive

(Spradling et al., 1999)

Phenotype Manifest In

egg chorion | maternal effect

(Costa et al., 2005)

ovary

(Digilio et al., 1996)

Detailed Description

Statement

Reference

A significant percentage of the eggs laid by orb^dec mutant mothers are ventralized.

(Costa et al., 2005)

Disrupts cyst formation near the time that the 16 cell cluster is formed and causes cyst degeneration. Ovaries are tiny, each ovariole consists of a germarium-like region and occasionally one or two egg chambers, egg chambers are often empty. Aberrant cellular morphology is seen in the germarial mid region, blebs appear on the surface of cystocytes (blebs are presumed to be the evidence of degenerating cells and cellular debris). orb^dec interacts genetically with Egfr and grk, double heterozygote embryos display fused dorsal appendages.

(Christerson and McKearin, 1994)

Oogenesis has blocked during a stage of cyst development, the ovaries are very small and consist of germarium like structures populated by many small undifferentiated cells.

(Lantz et al., 1994)

female-sterile ovaries tumorous

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

orb^dec is a non-enhancer of abnormal neuroanatomy phenotype of Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF

(Mutsuddi et al., 2004)

NOT Suppressor of

Statement

Reference

orb^dec is a non-suppressor of abnormal neuroanatomy phenotype of Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF

(Mutsuddi et al., 2004)

Other

Statement

Reference

L^si, hyx^EY06898, orb^dec has visible | adult stage phenotype

(Zhang et al., 2010)

Phenotype Manifest In

Suppressed by

Statement

Reference

orb^dec has egg chorion | maternal effect phenotype, suppressible by Fmr1³/Fmr1³

(Costa et al., 2005)

Other

Statement

Reference

L^si, hyx^EY06898, orb^dec has eye phenotype

(Zhang et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

Dominantly enhances the Df(1)N-54l9/+ wing nicking phenotype.

(Kankel et al., 2007)

Ventralization of eggshells laid by orb^dec mutant mothes is suppressed by Fmr1³/Fmr1³.

(Costa et al., 2005)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

10326

ry⁵⁰⁶ P{PZ}orb^dec/TM3, ry^RK Sb¹ Ser¹

Notes on Origin

Discoverer

A. Spradling.

(Lantz et al., 1994)

Comments

Class I orb allele.

(Lantz et al., 1994)

Precise excision of P{lacZ-ry⁺} reverts the mutant phenotype to wild type.

(Christerson and McKearin, 1994)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

dec

(Geng and MacDonald, 2007)

fs(3)00107

(Spradling et al., 1999)

fs(3)00107⁰⁰¹⁰⁷

orb⁰⁰¹⁰⁷

orb¹

orb^DEC

(Reveal et al., 2010)

orb^Dec

(Barr et al., 2019)

orb^dec

(Saha et al., 2023, Rojas-Ríos et al., 2015, Zhang et al., 2010, Kankel et al., 2007)

Name Synonyms

degenerating cysts

Secondary FlyBase IDs

FBal0024287

References (19)

Report Sections

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