FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\sogU2
Open Close
General Information
Symbol
Dmel\sogU2
Species
D. melanogaster
Name
FlyBase ID
FBal0039966
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Progenitor genotype
Associated Insertion(s)
Cytology
Description

Imprecise excision of P-element, deletion from within the element extending 1.4 to 1.6kb in the 3' direction eliminating flanking 5' genomic sequences, including the initiator ATG.

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Ventral sogU2 follicle cell clones are often associated with a small operculum. Dorsal sogU2 follicle cell clones are usually smaller than those located ventrally and generate no phenotype. However, fused dorsal appendages have been observed in the proximity of dorsal clones if they touch the base of the appendages.

Embryos produced from egg chambers with ventral sogU2 follicle cell clones have bifurcated or interrupted ventral denticle belts. These embryos are more dorsalized than those only lacking zygotic sogU2 function. Embryos generated from egg chambers with dorsal sogU2 follicle cell clones do not show these defects.

Eggs laid by sogU2/+ females have eggshells with short dorsal appendages and ectopic material deposited at the base in 2% of cases and 9% of eggs show fused or partially fused dorsal appendages.

Embryos resulting from germ-line clones homozygous for sogU2 show no defects in eggshell or cuticle. Embryos resulting from follicle cell clones homozygous for sogU2 show a reduction in denticles in parts or all along the AP axis of the embryo. In the most extreme cases denticle are absent. Shift between dorsal and lateral, and lateral and ventral fates occurs. 30% of eggs derived from follicle cell clones show dorsal appendages spaced abnormally far apart.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhancer of
Statement
Reference

sogU2 is an enhancer of mesoderm phenotype of dl15

Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

sogT:Ivir\HA1 rescues sogYL26/sogU2 mutants to viable and fertile adults.

sog+mPa rescues sogYL26/sogU2 mutants to viable and fertile adults.

Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
Comments
Comments

Significantly rescues haplo-insufficiency of dpp.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (13)