FlyBase Allele Report: Dmel\dl[15]

General Information

Symbol

Dmel\dl¹⁵

Species

D. melanogaster

Name

FlyBase ID

FBal0002657

Feature type

allele

Associated gene

Dmel\dl

Associated Insertion(s)

Carried in Construct

Also Known As

dl^I5, dorsal^I5

Key Links

Allele class

loss of function allele

amorphic allele - genetic evidence

Mutagen

X ray

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Isoda et al., 1992)

loss of function allele

(Biehs et al., 1996)

Mutagen

X ray

(Tearle and Nusslein-Volhard, 1987)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal immune response | conditional

(Bettencourt et al., 2004)

Phenotype Manifest In

embryonic/first instar larval cuticle

(Meng et al., 1999)

embryonic/first instar larval cuticle | ventral

(Bartoszewski et al., 2004)

mesoderm

(Araujo and Bier, 2000)

Detailed Description

Statement

Reference

Homozygous germ-line clones form completely dorsalised embryos.

(Bartoszewski et al., 2004)

dl¹⁵ mutant larvae dissected and exposed to air for 60 minutes show much reduced melanization, and melanin deposition on cuticles is substantially reduced compared to wild-type larvae under the same conditions.

(Bettencourt et al., 2004)

Lowering the dose of dl maternally reduced the width of the embryonic mesoderm from 18 cells to 12-14 cells.

(Araujo and Bier, 2000)

Embryos derived from homozygous females have a completely dorsalised cuticle. This phenotype is partially rescued if the females are also carrying dl^αTub84B.PM; the resulting embryos have well defined dorsoventral polarity and have ventral denticle belts.

(Meng et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Suppressor of

Statement

Reference

dl¹⁵ is a non-suppressor of melanotic mass phenotype | recessive | third instar larval stage phenotype of Atg6¹

(Shravage et al., 2013)

Phenotype Manifest In

Enhanced by

Statement

Reference

dl¹⁵ has mesoderm phenotype, enhanceable by sog^U2

(Araujo and Bier, 2000)

Suppressed by

Statement

Reference

dl¹⁵ has embryonic/first instar larval cuticle | ventral phenotype, suppressible by bai¹

(Bartoszewski et al., 2004)

dl¹⁵ has embryonic/first instar larval cuticle | ventral phenotype, suppressible by eca¹

(Bartoszewski et al., 2004)

Additional Comments

Genetic Interactions

Statement

Reference

dl¹⁵ fails to suppress the melanotic mass phenotype seen in Atg6¹ mutant third instar larvae.

(Shravage et al., 2013)

Homozygous dl¹⁵, eca¹ germ-line clones produce embryos that form cuticles lateralised at the filzkorper level - a long dorsalised cuticle with a characteristic filzkorper ring. Homozygous dl¹⁵, bai¹ germ-line clones produce embryos that form cuticles lateralised at the filzkorper level - a long dorsalised cuticle with a characteristic filzkorper ring.

(Bartoszewski et al., 2004)

The influence of sog mutants on the mesoderm of dl mutants is strictly maternal.

(Araujo and Bier, 2000)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

dl¹⁵ is partially rescued by dl^αTub84B.PM

(Meng et al., 1999)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

Dorsal¹⁵

(Nandy et al., 2018)

dl¹⁵

dl^I5

(Shravage et al., 2013, Fontenele et al., 2009, Bartoszewski et al., 2004, Meng et al., 1999, Zhou et al., 1998, Biehs et al., 1996, Rusch and Levine, 1994, Tearle and Nusslein-Volhard, 1987)

dlI5

(Carneiro et al., 2006)

Name Synonyms

dorsalI5

(Shravage et al., 2013, Bettencourt et al., 2004)

Secondary FlyBase IDs

References (15)

Report Sections

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