FlyBase Allele Report: Dmel\Adc[unspecified]

General Information

Symbol

Dmel\Adc^unspecified

Species

D. melanogaster

Name

FlyBase ID

FBal0042867

Feature type

allele

Associated gene

Dmel\Adc

Associated Insertion(s)

Carried in Construct

Also Known As

unspecified

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

FlyBase curator comment: this entry is used to capture phenotypic information when the particular allele (or allele combination) used by the author could not be determined but the context of the experiment suggests that the phenotype being described is some kind of loss of function.

(FlyBase Curators, 2025-)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal body color

(Simmons et al., 1999, Hilliker and Holm, 1975)

visible

(Morris et al., 2012)

visible | recessive

(Hilliker and Holm, 1975)

Phenotype Manifest In

adult cuticle

(Morris et al., 2012, Simmons et al., 1999)

Detailed Description

Statement

Reference

The cuticle of b^unspecified mutant flies is dark gray.

(Morris et al., 2012)

Body colour: flies have a black body colour.

(Simmons et al., 1999)

No sensitivity to 0.2M beta-alanine.

(Campbell and Sherald, 1987)

Body colour: black.

(Hilliker and Holm, 1975)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Adc^unspecified has visible phenotype, suppressible by r^Su(b).cSa

(Morris et al., 2012)

Adc^unspecified, r^Su(b).cSa has visible phenotype, suppressible by CRMP^supA4

(Morris et al., 2012)

Adc^unspecified has abnormal body color phenotype, suppressible by r^Su(b).cSa

(Simmons et al., 1999)

NOT suppressed by

Statement

Reference

Adc^unspecified has abnormal body color phenotype, non-suppressible by r^SA.cSa

(Simmons et al., 1999)

Adc^unspecified has abnormal body color phenotype, non-suppressible by r^SE.cSa

(Simmons et al., 1999)

Adc^unspecified has abnormal body color phenotype, non-suppressible by r^cSa

(Simmons et al., 1999)

Other

Statement

Reference

Adc^unspecified, CRMP^EGFP, CRMP^supA4, r^Su(b).cSa has visible phenotype

(Morris et al., 2012)

Adc^unspecified, CRMP^fs9a.EGFP, CRMP^supA4, r^Su(b).cSa has visible phenotype

(Morris et al., 2012)

Adc^unspecified, fs(1)pyr^Su(b), r^Su(b) has lethal | recessive | embryonic stage phenotype

(Piskur et al., 1999)

Adc^unspecified, fs(1)pyr^Su(b), r^Su(b)DK7 has lethal | recessive | embryonic stage phenotype

(Piskur et al., 1999)

Adc^unspecified, fs(1)pyr^Su(b), r^Su(b) has lethal | embryonic stage phenotype

(Piskur et al., 1999)

Phenotype Manifest In

Suppressed by

Statement

Reference

Adc^unspecified, r^Su(b).cSa has adult cuticle phenotype, suppressible by CRMP^supA4

(Morris et al., 2012)

Adc^unspecified has adult cuticle phenotype, suppressible by r^Su(b).cSa

(Morris et al., 2012)

Adc^unspecified has phenotype, suppressible by r^Su(b)

(Sondergaard and Kolbak, 1987, Pedersen, 1982)

Adc^unspecified has phenotype, suppressible by r^Su(b)DK7

(Sondergaard and Kolbak, 1987)

Other

Statement

Reference

Adc^unspecified, CRMP^EGFP, CRMP^supA4, r^Su(b).cSa has adult cuticle phenotype

(Morris et al., 2012)

Adc^unspecified, CRMP^fs9a.EGFP, CRMP^supA4, r^Su(b).cSa has adult cuticle phenotype

(Morris et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

r^Su(b).cSa suppresses the b^unspecified body colour phenotype resulting in a brownish cuticle.

CRMP^supA4 disrupts the suppression of the body colour phenotype of b^unspecified mutants by r^Su(b).cSa.

CRMP^{T:Avic\GFP-EGFP} supports the suppression of the body colour phenotype of b^unspecified, CRMP^supK1 double mutants by r^Su(b).cSa resulting in a brownish cuticle.

CRMP^{fs9a.T:Avic\GFP-EGFP} fails to support the suppression of the body colour phenotype of b^unspecified, CRMP^supA4/CRMP^supK1 double mutants by r^Su(b).cSa resulting in a dark gray cuticle.

CRMP^{fs9b.T:Avic\GFP-EGFP} supports the suppression of the body colour phenotype of b^unspecified, CRMP^supA4/CRMP^supK1 double mutants by r^Su(b).cSa resulting in a brownish cuticle.

(Morris et al., 2012)

Embryos that are homozygous for fs(1)pyr^Su(b) r^Su(b) and b^unspecified and originate from a female homozygous for these 3 mutations show reduced viability; most progeny die at early developmental stages. Embryos that are homozygous for fs(1)pyr^Su(b) r^Su(b)DK7 and b^unspecified and originate from a female homozygous for these 3 mutations show severely reduced viability. Newly laid eggs begin development normally, and early embryogenesis proceeds normally through the syncytial blastoderm, gastrulation and extended germ band stages. Abnormalities such as shrinkage of the embryo and lack of muscle contraction are seen near the end of embryogenesis and the majority of embryos die just before the eggs are due to hatch.

(Piskur et al., 1999)

The b^unspecified black body colour phenotype is suppressed by r^Su(b).cSa but not by r^cSa, r^SE.cSa or r^SA.cSa.

(Simmons et al., 1999)

r^Su(b) b^unspecified flies retain wild-type body colour in the presence of 6-azathymine.

(Pedersen, 1982)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Mutants are able to synthesize β-alanyl-dopamine.

(Perez et al., 1997)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Adc^unspecified

b^unspecified

unspecified

(Campbell and Sherald, 1987, Pedersen, 1982, Hilliker and Holm, 1975)

Name Synonyms

Secondary FlyBase IDs

References (12)

Report Sections

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