egh^cm females are insensitive to injection with sex peptide; oviposition is not induced in these females and mating is not suppressed. This phenotype is also seen in egh^cm/egh⁷ and egh^cm/Df(1)K95 transheterozygotes.

Remating in egh^cm and egh^cm/egh⁷ females is about 48% and 24% compared to mating of virgin egh^cm and egh^cm/egh⁷ females, which is a higher amount than in control females. Sex appeal of mated egh^cm/egh⁷ females to males is reduced to the same extent as control mated females.

Egg laying is not induced in egh^cm females after mating with a wild-type male.

The central brain of egh^cm adults appears largely normal but the medulla in the optic lobes is not rotated and as a consequence the first optic chiasm is missing. Analysis of optic lobe development reveals that photoreceptor neurons show defects in target recognition.

In larval brains of egh^cm/egh⁷ mutants, Ap neurons projecting from the VNC to the CNS show pathfinding errors and fail to reach the target area. In many cases, these axons defasciculate and turn backward. Mostly, these axons stop extending toward the central brain but rarely defasciculate.

Variable defects in oogenesis: follicles have either more or less that the normal number of 16 germ cells (erroneous splitting and/or fusion of correct clusters of 16 cystocytes). Position of the oocyte within the follicle is variable and the shape of the nurse cells is often irregular: both these indicate a flexible structure of the germ cell cluster. The microtubular organisation in the oocyte and nurse cell transport to the oocyte is also affected. A second oocyte can develop anywhere within the cluster, altered cell fate of a presumptive nurse cell: instead of the pro-oocytes, germ cells 5 and 6 differentiate into an oocyte. Germline clones exhibit the same phenotype as homozygous females.

Viability reduced by 50%. Surviving females are completely sterile. Germ cell number, follicle polarity and oocyte-nurse cell differentiation are affected. Retained eggs often have fused dorsal appendages. Surviving males have small, rough eyes. Double heterozygotes with Egfr alleles of the 'torpedo' class rarely survive, and double heterozygotes with Egfr 'Ellipse' alleles have a marked reduction in number or ommatidia. Double heterozygotes with Dl alleles never survive, and embryos show neurogenic phenotypes.