FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\retn05096
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General Information
Symbol
Dmel\retn05096
Species
D. melanogaster
Name
FlyBase ID
FBal0043418
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
l(2)05096
Key Links
Genomic Maps

Allele class
Nature of the Allele
Allele class
Progenitor genotype
Associated Insertion(s)
Cytology
Description

The P{PZ} insertion is upstream of the first exon of the retn gene.

P{PZ} insertion 439bp upstream of the retn transcription start site.

Allele components
Component
Use(s)
Inserted element
Encoded product / tool
Mutations Mapped to the Genome
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

retnz2-428/retn05096 females exhibit male like courtship behaviours. Mutant females follow, tap and appear to sing. Although not as robust as male courtship - following is not as sustained, full wing extension and vibration is not seen, and copulatory bending is weak or absent - these behaviours resemble courtship. The peak penetrance of these phenotypes is 3-4 weeks post eclosion, averaging 42 courtship events per 5 minute observation period (compared to <3 in controls). male-male and male-female courtship in retnz2-428/retn05096 mutant males is comparable to wild-type. retn05096/retnz2-428 animals also exhibit mushroom body (MB) specific abnormalities. A subset of MB neurons diverge within the nerve tracks and axons from the posterior part of the β-lobe neurons cross the midline and join with the opposite β-lobe neurons, causing β-lobe fusion. This is more common in females than in males.

Both zygotic and germline clone homozygous embryos have a normal pattern of cuticle structures.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Enhanced by
NOT suppressed by
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

A. Spradling.

Comments
Comments

Alleles fall into an allelic series in terms of pre-adult mortality: retn2 > retn1 > retn89.GAL4 > retn05096 > retnz2-428 > retnRU50.

Complements: ken00628. Complements: Dcp-101862. Complements: Dcp-102121. Complements: apt03041. Complements: apt06369. Complements: apt07010. Complements: apt09049. Complements: Dcp-1k05606. Complements: aptk15608.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (6)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (6)