FB2026_02 , released June 18, 2026
Allele: Dmel\l(2)gd14
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General Information
Symbol
Dmel\l(2)gd14
Species
D. melanogaster
Name
FlyBase ID
FBal0043606
Feature type
allele
Associated gene
Dmel\l(2)gd1
Associated Insertion(s)
Carried in Construct
Also Known As
lgdd4
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Agrawal et al., 1995)
Mutagen
X ray
(Agrawal et al., 1995)
Progenitor genotype
Cytology
Description

A 2 bp deletion at amino acid position 215 which results in a frame shift and a translational stop 14 amino acids downstream, leading to a truncated protein containing only the first DM14 domain.

(Jaekel and Klein, 2006)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
2L:11,107,795..11,107,796 [+]
Comment:

A two base pair deletion within amino acid 215 that results in a frameshift and translation termination 14aa downstream. The two deleted bases within the codon were not specified.

(Jaekel and Klein, 2006)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Pupal escapers are very rare. l(2)gd11/l(2)gd14 trans-heterozygotes survive to third instar larvae, show an extended larval life and imaginal discs show extensive hyperplasia. Clones in a vg1 homozygous background are recognisable by growths protuding from the wing blade, thus partially restoring the wing pattern by extensions of the wing blade areas (three-fold increase in wing blade area) and a span of clonal tissue in both dorsal and ventral wing surfaces.

      (Agrawal et al., 1995)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      l(2)gd11, l(2)gd14, l(2)gd1d7 and l(2)gd1d10 all harbor the same lesion.

      (Jaekel and Klein, 2006)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      l(2)gd14
      lgdd4
      (Gallagher and Knoblich, 2006, Jaekel and Klein, 2006, Klein, 2003)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)