FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\abs04505
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General Information
Symbol
Dmel\abs04505
Species
D. melanogaster
Name
FlyBase ID
FBal0043628
Feature type
allele
Associated gene
Dmel\abs
Associated Insertion(s)
P{PZ}abs04505
Carried in Construct
Also Known As
l(3)04505
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Schmucker et al., 2000)
Mutagen
P-element activity
(Schmucker et al., 1997)
Progenitor genotype
Associated Insertion(s)
P{PZ}abs04505
Cytology
Description

The P{PZ} insertion is 77 nucleotides upstream of the start codon of the abs gene.

(Schmucker et al., 2000)
Allele components
Component
Use(s)
Inserted element
P{PZ}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      In homozygous abs04505 mutants aberrant central nervous system (CNS) fibres can be observes in then intercommissural space and the connectives are weakened and occasionally absent. Overall the CNS appears less compact than in wild-type.

      (Schmucker et al., 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      abs00620

      (BDGP Project Members, 1994-1999)
      Partially rescued by

      abs04505 is partially rescued by abs+t5.8

      (Irion and Leptin, 1999)
      Comments

      Lethality is suppressed by the addition of abs+t5.8.

      (Irion and Leptin, 1999)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      A. Spradling.

      Comments
      Comments

      Phenotypic analysis provides an allelic series: absE2 << abs04505 = abs00620 < absII-F1 = abs45LR7.

      (Schmucker et al., 2000)

      Complements: l(3)0094500945. Complements: ttv02055.

      (BDGP Project Members, 1994-1999)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      abs04505
      absP4505
      (Schmucker et al., 2000)
      l(3)04505
      (Irion and Leptin, 1999, Schmucker et al., 1997)
      l(3)0450504505
      Name Synonyms
      Secondary FlyBase IDs
        References (5)