FlyBase Allele Report: Dmel\vvl[GA3]

General Information

Symbol

Dmel\vvl^GA3

Species

D. melanogaster

Name

FlyBase ID

FBal0044443

Feature type

allele

Associated gene

Dmel\vvl

Associated Insertion(s)

Carried in Construct

Also Known As

vvl^6A3

Key Links

Allele class

loss of function allele

Mutagen

X ray

Nature of the Allele

Allele class

loss of function allele

(de Celis et al., 1995)

Mutagen

X ray

(de Celis et al., 1995)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy

(Inbal et al., 2003)

increased cell death

(Inbal et al., 2003)

lethal - all die during embryonic stage | recessive

(Inbal et al., 2003, de Celis et al., 1995)

some die during embryonic stage | recessive

(Inbal et al., 2003, de Celis et al., 1995)

Phenotype Manifest In

adult abdominal sensillum (with vvl^M638)

(Inbal et al., 2003)

adult head bristle (with vvl^M638)

(Inbal et al., 2003)

adult thoracic sensillum (with vvl^M638)

(Inbal et al., 2003)

embryonic/larval tracheal dorsal trunk | embryonic stage

(de Celis et al., 1995)

embryonic abdominal lateral sensory organ precursor cluster

(Inbal et al., 2003)

filzkorper

(de Celis et al., 1995)

larval abdominal lch5 neuron

(Inbal et al., 2003)

larval longitudinal connective

(de Celis et al., 1995)

larval tracheal system

(Llimargas and Casanova, 1999)

macrochaeta | ectopic

(de Celis et al., 1995)

presumptive embryonic/larval central nervous system

(de Celis et al., 1995)

sensory neuron

(Inbal et al., 2003)

symmetrical commissure

(de Celis et al., 1995)

tracheal section

(Sánchez-Higueras et al., 2014, de Celis et al., 1995)

ventral denticle belt

(de Celis et al., 1995)

wing

(de Celis et al., 1995)

wing & macrochaeta

(de Celis et al., 1995)

wing blade posterior compartment

(de Celis et al., 1995)

wing vein

(de Celis et al., 1995, Sturtevant and Bier, 1995)

Detailed Description

Statement

Reference

Traheal migration is affected in vvl^GA3 mutants. The cells form and then degenerate.

(Sánchez-Higueras et al., 2014)

The lch5 neurons are situated in a more dorsal position than normal in 60-70% of abdominal segments in mutant embryos. If the lch5 neurons are situated just above the dorsal bipolar dendrite neuron, their dendrites point ventroposteriorly. The v'ch1 neuron is in its normal position. Mutant embryos show a loss of mild loss of es neurons. Many more apoptotic nuclei than normal are seen in the lateral clusters of the peripheral nervous system of mutant embryos. A small fraction of vvl^M638/vvl^GA3 animals develop to pharate adults which have bristle defects on the head thorax and abdomen.

(Inbal et al., 2003)

Defects in tracheal invagination are seen in stage 12 embryos.

(Llimargas and Casanova, 1999)

Loss of vein mutation. Suppression of rho^hs.PSt ectopic vein phenotype and enhancement of the rho^ve-1 loss of vein phenotype.

(Sturtevant and Bier, 1995)

Mutant embryos show reduced width of denticle belts (reminiscent of mutations in the spitz group of genes). Denticle belts are disturbed particularly in the third thoracic segment and the regular spacing of the commissures and connectives of the CNS is perturbed. Filzkorpers have abnormal shape suggesting that their connection to the tracheal trunk has failed. Dorsal trunk and branches of the tracheal system are lacking. Instead the tracheal pits form abnormal cavities that remain disconnected. Clones in the wing are smaller than controls and affect the differentiation of wing structures. In proximal regions they cause fusion of vein trunks and both dorsal and ventral clones autonomously fail to differentiate veins. The effect is restricted to the surface in which the clone lies. Dorsal clones in veins LIII and LIV cause both loss of and thickened vein, often resulting in folding of the wing. Ventral clones in the posterior compartment close to vein LIV can cause vein loss. Veins in the anterior wing margin are not affected. Dorsal and ventral clones between veins LIII and LV produce ectopic bristles, with features of wing margin bristles.

(de Celis et al., 1995)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^btl.PS, tkv^{Q253D.UAS.cLa}, vvl^GA3 has tracheocyte phenotype, suppressible by btl^hs.PM

(Llimargas and Casanova, 1997)

Scer\GAL4^btl.PS, tkv^{Q253D.UAS.cLa}, vvl^GA3 has larval tracheal system phenotype, suppressible by btl^hs.PM

(Llimargas and Casanova, 1997)

Other

Statement

Reference

Df(3L)H99, vvl^GA3 has tracheal section phenotype

(Sánchez-Higueras et al., 2014)

Scer\GAL4^btl.PS, tkv^{Q253D.UAS.cLa}, vvl^GA3 has larval tracheal system phenotype

(Llimargas and Casanova, 1997)

Scer\GAL4^btl.PS, tkv^{Q253D.UAS.cLa}, vvl^GA3 has tracheocyte phenotype

(Llimargas and Casanova, 1997)

Additional Comments

Genetic Interactions

Statement

Reference

vvl^GA3 mutants in a Df(3L)H99 background display defects in tracheal development. The primordia undergo epithelial-mesenchymal transition and migrate up to the primordia coalescence; however, the later dorsal migration does not progress.

(Sánchez-Higueras et al., 2014)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

dfr/vvl^6A3

(Zelzer and Shilo, 2000)

vvl^6A3

(Chung et al., 2011, Llimargas and Casanova, 1999, Llimargas and Casanova, 1997, de Celis et al., 1995)

vvl^GA3

(Ogura et al., 2018, Yao et al., 2017, Sánchez-Higueras et al., 2014, Sotillos et al., 2010, Araujo et al., 2007)

vvlGA3

(Sotillos et al., 2010)

Name Synonyms

Secondary FlyBase IDs

References (14)

Report Sections

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