FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\NrtM221
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General Information
Symbol
Dmel\NrtM221
Species
D. melanogaster
Name
FlyBase ID
FBal0044722
Feature type
allele
Associated gene
Dmel\Nrt
Associated Insertion(s)
Carried in Construct
Also Known As
dabM221
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
X ray
(Hill et al., 1995)
ethyl methanesulfonate
(Liebl et al., 2003, Hill et al., 1995)
Progenitor genotype
Cytology
Description

Amino acid replacement: G368E.

(Liebl et al., 2003)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:16,774,922..16,774,922 [+]
Nucleotide change:

G16774922A

Amino acid change:

G368E | Nrt-PA; G368E | Nrt-PB; G368E | Nrt-PC

Reported amino acid change:

G368E

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Liebl et al., 2003)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      Abl4/Abl1, NrtM221/Nrt[+] has lethal | prepupal stage phenotype, suppressible by ena[+]/enaGC10

      (Liebl et al., 2000)
      Enhancer of
      Statement
      Reference

      NrtM221/Nrt[+] is an enhancer of lethal | prepupal stage phenotype of Abl4/Abl1

      (Liebl et al., 2000)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Induced on: Abl1. The NrtM221 mutant allele was originally thought to be a mutation in the Dab gene (see FBrf0049327, FBrf0058531 and FBrf0084025), but sequencing of the chromosome indicates that it is a lesion in the Nrt gene.

      (Liebl et al., 2003)

      Induced on: Abl1.

      (Hill et al., 1995)
      Comments
      Comments

      "X ray" was stated as tentative. "ethyl methanesulfonate" was stated as tentative. Haploinsufficiency dependent upon an Abl mutant background (HDA).

      (Hill et al., 1995)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (6)
      Reported As
      Symbol Synonym
      Dabm2-21
      NrtM221
      dab221
      (Le and Simon, 1998)
      dabM221
      (Liebl et al., 2003, Liebl et al., 2000)
      dabM221
      (Hill et al., 1995)
      nrtM221
      (Liebl et al., 2003)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)