FB2026_02 , released June 18, 2026
Allele: Dmel\Hsf2
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General Information
Symbol
Dmel\Hsf2
Species
D. melanogaster
Name
FlyBase ID
FBal0044862
Feature type
allele
Associated gene
Dmel\Hsf
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Jedlicka et al., 1997)
Mutagen
ethyl methanesulfonate
(Jedlicka et al., 1997, Jedlicka et al., 1996)
Progenitor genotype
Cytology
Description

Amino acid replacement: Q373term.

(Jedlicka et al., 1997)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:18,132,144..18,132,144 [-]
Nucleotide change:

C18132144T

Amino acid change:

Q373term | Hsf-PA; Q373term | Hsf-PB; Q373term | Hsf-PC; Q373term | Hsf-PD

(Jedlicka et al., 1997)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygotes usually arrest at the 1st or 2nd larval instar stage and die after 2-3 days without any further growth or development, although some viable adults are produced. Hsf2 is lethal in combination with Df(2R)PclP2. Viability is rescued in homozygous or hemizygous Hsf2/Df(2R)PclP2 flies carrying Hsf+t8. Females mosaic for homozygous clones in the germ line are sterile.

      (Jedlicka et al., 1997)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Hsf2 is rescued by Hsf+t8

      (Jedlicka et al., 1997)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Hsf2
      Name Synonyms
      Secondary FlyBase IDs
        References (2)