FlyBase Allele Report: Dmel\Con[Fvex238]

General Information

Symbol

Dmel\Con^Fvex238

Species

D. melanogaster

Name

FlyBase ID

FBal0048135

Feature type

allele

Associated gene

Dmel\Con

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

loss of function allele

hypomorphic allele - genetic evidence

Mutagen

PM hybrid dysgenesis

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Nose et al., 1994)

loss of function allele

(Nose et al., 1997)

Mutagen

PM hybrid dysgenesis

(Nose et al., 1994)

Progenitor genotype

Con^rF400

(Nose et al., 1994)

Cytology

Description

Imprecise excision and small deletion (less than 2kb) of sequences within the first intron.

(Nose et al., 1994)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable

(Nose et al., 1997, Nose et al., 1994)

Phenotype Manifest In

larval abdominal segmental nerve | embryonic stage

(Nose et al., 1997)

Detailed Description

Statement

Reference

SNa motoneurons often inappropriately innervate a neighbouring non-target muscle, muscle 12, when Con is ectopically expressed. Ectopic innervation of muscle 12 is only rarely observed in a Con^Fvex238 genetic background, innervation of the native SNa target muscles is normal.

(Nose et al., 1997)

In homozygous embryos the SNb fails to diverge from the ISN partially (partial bypass) in 2% segments and the SNc partially fails in 1% segments. Con^Fvex238suppresses the SNc divergence defect of beat-Ia² and beat-Ia³ flies.

(Fambrough and Goodman, 1996)

The overall pattern of nerve branching and innervation appears normal.

(Nose et al., 1994)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressor of

Statement

Reference

Con^Fvex238 is a suppressor of larval abdominal segmental nerve phenotype of Fas2^EB112, Sema1a^k13702

(Yu et al., 2000)

NOT Suppressor of

Statement

Reference

Con^Fvex238 is a non-suppressor of larval abdominal segmental nerve phenotype of Sema1a^k13702

(Yu et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

The Sema-1a^k13702 segmental nerve a (SNa) defasciculation defects are not suppressed by Con^Fvex238 alone. However, rescue of the Sema-1a^k13702 SNa stall phenotype is seen in Fas2^EB112/+ ; Sema-1a^k13702 ; Con^Fvex238 triple mutant embryos; the SNa dorsal branches bifurcate at lateral muscles (LMs) 22-23 and extend dorsally.

(Yu et al., 2000)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Con^Fvex238

conn^Fvex238

(Yu et al., 2000)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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