FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Klc59A
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General Information
Symbol
Dmel\Klc59A
Species
D. melanogaster
Name
FlyBase ID
FBal0048837
Feature type
allele
Associated gene
Dmel\Klc
Associated Insertion(s)
P{lacW}Klc59A
Carried in Construct
Also Known As
klc1
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(Desai et al., 1996)
Progenitor genotype
mirrcre2
(Desai et al., 1996)
Associated Insertion(s)
P{lacW}Klc59A
Cytology
Description

P{lacW} insertion in the first intron of Klc.

(Gindhart et al., 1998)

P{lacW} has inserted into an intron in the Klc transcription unit.

(Desai et al., 1996)
Allele components
Component
Use(s)
Inserted element
P{lacW}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygotes die during the midpupal stage. Klc8ex94/Klc59A animals survive until the late third larval instar stage. Klc8ex94/Klc59A larvae flip their posterior end off the surface of the food during crawling.

      (Gindhart et al., 1998)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescued by

      Klc59A/Klc8ex94 is partially rescued by KlcUbi-p63E.Tag:MYC

      (Gindhart et al., 1998)

      Klc59A/Klc8ex94 is partially rescued by KlcGEN

      (Gindhart et al., 1998)

      Klc59A is partially rescued by KlcUbi-p63E.Tag:MYC

      (Gindhart et al., 1998)

      Klc59A is partially rescued by KlcGEN

      (Gindhart et al., 1998)
      Comments

      KlcGEN rescues Klc8ex94/Klc59A animals to adulthood, but the lethality of Klc59A homozygotes is rescued only from the midpupal stage to the late pupal stage. Homozygous lethality is partially rescued by KlcUbi-p63E.T:Hsap\MYC. KlcUbi-p63E.T:Hsap\MYC rescues Klc8ex94/Klc59A animals to adulthood. Klc8ex94/Klc59A larvae flip their posterior end off the surface of the food during crawling. This phenotype is rescued by KlcGEN and KlcUbi-p63E.T:Hsap\MYC.

      (Gindhart et al., 1998)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Complements lethal mutations in Ptp69D. Klc59A revertants in which the P{lacW} element has been excised complement Klc59A.

      (Gindhart et al., 1998)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Klc1
      (Ray et al., 1999, Gindhart et al., 1998)
      Klc59A
      klc1
      (Palacios and St. Johnston, 2002)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)