FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\RpS17unspecified
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General Information
Symbol
Dmel\RpS17unspecified
Species
D. melanogaster
Name
FlyBase ID
FBal0048872
Feature type
allele
Associated gene
Dmel\RpS17
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    FlyBase curator comment: this entry is used to capture phenotypic information when the particular allele (or allele combination) used by the author could not be determined but the context of the experiment suggests that the phenotype being described is some kind of loss of function.

    (FlyBase Curators, 2025-)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        RpS17unspecified is cell lethal in homozygous clones of cells.

        (Bhattacharya and Baker, 2009)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Suppressor of
        Statement
        Reference

        RpS17unspecified is a suppressor of lethal | somatic clone phenotype of emcAP6

        (Bhattacharya and Baker, 2011)
        Phenotype Manifest In
        Enhancer of
        Statement
        Reference

        RpS17unspecified is an enhancer of phenotype of run3

        (Duffy et al., 1996)
        Suppressor of
        Statement
        Reference

        RpS17unspecified is a suppressor of eye disc | somatic clone phenotype of emcAP6

        (Bhattacharya and Baker, 2011)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Homozygous emcAP6 clones only survive in imaginal discs when induced in a background heterozygous for RpS17unspecified. emcAP6 clones accelerate the morphogenetic furrow and often initiate ectopic morphogenetic furrows from the lateral eye margin. Clones are also associated with sporadic neuronal differentiation anterior to the furrow and in the peripodial membrane, although such ectopic neurons do not adopt the R8 photoreceptor cell fate.

        (Bhattacharya and Baker, 2011)

        When homozygous drprΔ5 clones (which are RpS17+) are induced in a background that is RpS17unspecified/+ ; drprΔ5/+, cell competition appears to be reduced, as the RpS17unspecified/+ ; drprΔ5/+ cells contribute to more of the territory and show reduced cell death compared to experiments where they are competing against +/+ cells.

        When homozygous Rac1EY05848 clones (which are RpS17+) are induced in a RpS17unspecified/+ background, cell competition appears to be reduced, as the RpS17unspecified/+ cells contribute to more of the territory and show reduced cell death compared to experiments where they are competing against +/+ cells.

        (Li and Baker, 2007)

        Acts as a dosage sensitive maternal modifier of run : causes tergite defects in greater than 50% of run3 heterozygotes.

        (Duffy et al., 1996)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        RpS17unspecified
        unspecified
        (Duffy et al., 1996)
        Name Synonyms
        Secondary FlyBase IDs
          References (5)