FlyBase Allele Report: Dmel\mts[XE-2202]

General Information

Symbol

Dmel\mts^XE-2202

Species

D. melanogaster

Name

FlyBase ID

FBal0048908

Feature type

allele

Associated gene

Dmel\mts

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

X ray

Nature of the Allele

Allele class

Mutagen

X ray

(Karim et al., 1996, Wassarman et al., 1996)

Progenitor genotype

Cytology

Description

Deletion in the second exon of bases 202-206 and an insertion of GGCAAGTGAAG in the same location, resulting in a frameshift. Mutant product would encode 67/309 mts amino acids followed by 6 amino acids of extra sequence.

(Wassarman et al., 1996)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

delins

2L:7,830,561..7,830,565 [+]

Inserted_sequence:

GGCAAGTGAAG

Comment:

mts[XE-2202] is a deletion of 5 bases and an insertion of GGCAAGTGAAG at the same location resulting in a frameshift.

(Wassarman et al., 1996)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Karim et al., 1996)

lethal - all die during embryonic stage | recessive

(Wassarman et al., 1996)

some die during embryonic stage | recessive

(Wassarman et al., 1996)

Phenotype Manifest In

Detailed Description

Statement

Reference

Homozygous clones are not recovered in the eye. Germ line clones reveal that oogenesis is blocked at stage 5.

(Wassarman et al., 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

mts[+]/mts^XE-2202 is an enhancer | maternal effect of female semi-sterile | dominant phenotype of gwl^scant, polo[+]/polo¹

(Rangone et al., 2011)

Suppressor of

Statement

Reference

mts^XE-2202 is a suppressor of visible phenotype of Dsor1^XS520

(Karim et al., 1996)

mts^XE-2202 is a suppressor of lethal phenotype of Raf¹²

(Karim et al., 1996)

Other

Statement

Reference

mts^XE-2202, polo[+]/polo¹ has female fertile phenotype

(Rangone et al., 2011)

mts^XE-2202, polo[+]/polo¹¹ has female semi-sterile | dominant phenotype

(Rangone et al., 2011)

gwl^scant, mts[+]/mts^XE-2202, polo[+]/polo¹¹ has female sterile | dominant phenotype

(Rangone et al., 2011)

gwl^scant, mts[+]/mts^XE-2202, polo[+]/polo¹ has female sterile | dominant phenotype

(Rangone et al., 2011)

gwl[+]/gwl^scant, mts^XE-2202 has female semi-sterile | dominant phenotype

(Rangone et al., 2011)

Phenotype Manifest In

Enhancer of

Statement

Reference

mts^XE-2202 is an enhancer of phenotype of Ras85D^V12.sev

(Karim et al., 1996)

mts^XE-2202 is an enhancer of eye phenotype of Ras85D^V12.sev

(Wassarman et al., 1996)

Suppressor of

Statement

Reference

mts^XE-2202 is a suppressor of wing hair | increased number phenotype of Scer\GAL4^ap-md544, wdb^EP3559

(Hannus et al., 2002)

mts^XE-2202 is a suppressor of eye phenotype of Dsor1^XS520

(Karim et al., 1996)

mts^XE-2202 is a suppressor of eye phenotype of Raf¹²

(Karim et al., 1996)

Additional Comments

Genetic Interactions

Statement

Reference

mts^XE-2202/+ enhances the reduced fertility phenotype of polo¹/+ gwl^scant/+ double heterozygous females, such that the triple heterozygotes are completely sterile.

(Rangone et al., 2011)

Enhances the rough eye phenotype of Ras85D^V12.sev. Has little or no effect on the phenotype of Ras85D^N17.sev. Slightly enhances the phenotype of phl::tor^13D.hs.sev. Enhances the phenotype of Ras85D::Src64B^{V12.ΔCAAX.sev}. Suppresses the lethality of phl¹². Slightly suppresses the phl¹² eye phenotype. Slightly suppresses the Dsor1^XS520 eye phenotype.

(Karim et al., 1996)

Weak enhancer of rough eye phenotype of Ras85D^V12.sev.

(Wassarman et al., 1996)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

Pp2A-28D²²⁰²

(Wassarman et al., 1996)

Pp2A-28D^XE-2202

mts2202

(Hannus et al., 2002)

mts^E2202

(Rangone et al., 2011)

mts^XE-2202

(Liaw and Chiang, 2019)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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