FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Su(Tpl)XS-706
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General Information
Symbol
Dmel\Su(Tpl)XS-706
Species
D. melanogaster
Name
FlyBase ID
FBal0048983
Feature type
allele
Associated gene
Dmel\Su(Tpl)
Associated Insertion(s)
Carried in Construct
Also Known As
SR3-4AXS-706
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
X ray
(Karim et al., 1996)
Progenitor genotype
Cytology
Description

Amino acid replacement: G501S.

(Eissenberg, 2003.4.16)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:19,893,203..19,893,203 [-]
Reported amino acid change:

G501S

Comment:

Site of the reported mutation in Su(Tpl)XS-706. The reported change is G501S but the residue is already a Ser in the reference sequence.

(Eissenberg, 2003.4.16)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The hetero-allelic combination Su(Tpl)s1/Su(Tpl)XS-706 is embryonic lethal. Mutant cuticles display the following defects, with variable penetrance: fusion of abdominal segments 3 and 4; fusion of abdominal segments 5 and 6; abdominal segment 2 missing; abdominal segment 1 incomplete. The hetero-allelic combination Su(Tpl)XS-706/Su(Tpl)S-192 is embryonic lethal. Mutant cuticles display the following defects, with variable penetrance: metathoracic segment missing or fused to mesothoracic segment; abdominal segments 1, 2 and 4 often incomplete.

      (Eissenberg et al., 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      Su(Tpl)XS-706/Su(Tpl)[+] is an enhancer of wing margin phenotype of Nnd-1

      (Eissenberg et al., 2002)

      Su(Tpl)XS-706/Su(Tpl)[+] is an enhancer of wing margin phenotype of ct53d

      (Eissenberg et al., 2002)
      Suppressor of
      Statement
      Reference

      Su(Tpl)XS-706 is a suppressor of phenotype of Ras85DV12.sev

      (Karim et al., 1996)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Suppresses the rough eye phenotype of Ras85DV12.sev. Has little or no effect on the phenotype of Ras85DN17.sev. Has little or no effect on the phenotype of phl::tor13D.hs.sev. Suppresses the phenotype of Ras85D::Src64BV12.ΔCAAX.sev. Has little or no effect on the lethality of phl12. Has little or no effect on the phl12 eye phenotype. Has little or no effect on the Dsor1XS520 eye phenotype. Slightly enhances the aopS2382 eye phenotype.

      (Karim et al., 1996)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      SR3-4AXS-706
      (Eissenberg et al., 2002, Karim et al., 1996)
      SR3-4axs706
      (Neufeld et al., 1998)
      Su(Tpl)XS-706
      Name Synonyms
      Secondary FlyBase IDs
        References (4)