FlyBase Allele Report: Dmel\ab[1D]

FB2026_01 , released March 12, 2026

FB2026_01 , released March 12, 2026

Allele: Dmel\ab^1D

General Information

Symbol

Dmel\ab^1D

Species

D. melanogaster

Name

FlyBase ID

FBal0049273

Feature type

allele

Associated gene

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - genetic evidence

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Hu et al., 1995)

Mutagen

Delta2-3 transposase

(Hu et al., 1995)

Progenitor genotype

ab⁹⁴

(Hu et al., 1995)

Associated Insertion(s)

Cytology

Description

0.7kb deletion removing exon 1 of ab. The P{lwB} of ab⁹⁴ has reinserted in the same position but opposite orientation.

(Hu et al., 1995)

Allele components

Component

Use(s)

Inserted element

Encoded product / tool

reporter enzyme

Tagged with

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

male sterile | recessive

(Hu et al., 1995)

visible | dominant

(Caygill and Johnston, 2008)

Phenotype Manifest In

campaniform sensillum of dorsal radius (with ab¹)

(Hu et al., 1995)

larval abdominal segmental nerve

(Hu et al., 1995)

larval transverse nerve

(Hu et al., 1995)

leg (with ab¹)

(Hu et al., 1995)

macrochaeta & wing (with ab¹)

(Hu et al., 1995)

male genitalia (with ab¹)

(Hu et al., 1995)

muscle cell of abdominal 2 dorsal acute muscle 3

(Hu et al., 1995)

muscle cell of abdominal 2 dorsal oblique muscle 3

(Hu et al., 1995)

muscle cell of abdominal 2 dorsal oblique muscle 5

(Hu et al., 1995)

muscle cell of abdominal 2 lateral oblique muscle 1

(Hu et al., 1995)

muscle cell of abdominal 3 dorsal acute muscle 3

(Hu et al., 1995)

muscle cell of abdominal 3 dorsal oblique muscle 3

(Hu et al., 1995)

muscle cell of abdominal 3 dorsal oblique muscle 5

(Hu et al., 1995)

muscle cell of abdominal 3 lateral oblique muscle 1

(Hu et al., 1995)

muscle cell of abdominal 4 dorsal acute muscle 3

(Hu et al., 1995)

muscle cell of abdominal 4 dorsal oblique muscle 3

(Hu et al., 1995)

muscle cell of abdominal 4 dorsal oblique muscle 5

(Hu et al., 1995)

muscle cell of abdominal 4 lateral oblique muscle 1

(Hu et al., 1995)

muscle cell of abdominal 5 dorsal acute muscle 3

(Hu et al., 1995)

muscle cell of abdominal 5 dorsal oblique muscle 3

(Hu et al., 1995)

muscle cell of abdominal 5 dorsal oblique muscle 5

(Hu et al., 1995)

muscle cell of abdominal 5 lateral oblique muscle 1

(Hu et al., 1995)

muscle cell of abdominal 6 dorsal acute muscle 3

(Hu et al., 1995)

muscle cell of abdominal 6 dorsal oblique muscle 3

(Hu et al., 1995)

muscle cell of abdominal 6 dorsal oblique muscle 5

(Hu et al., 1995)

muscle cell of abdominal 6 lateral oblique muscle 1

(Hu et al., 1995)

muscle cell of abdominal 7 dorsal acute muscle 3

(Hu et al., 1995)

muscle cell of abdominal 7 dorsal oblique muscle 3

(Hu et al., 1995)

muscle cell of abdominal 7 dorsal oblique muscle 5

(Hu et al., 1995)

muscle cell of abdominal 7 lateral oblique muscle 1

(Hu et al., 1995)

(Caygill and Johnston, 2008)

wing vein (with ab¹)

(Hu et al., 1995)

wing vein (with ab⁹⁴)

(Hu et al., 1995)

Detailed Description

Statement

Reference

Heterozygotes show an increase in wing size compared to controls.

(Caygill and Johnston, 2008)

During embryogenesis the SNb axons pause at the edge of muscle 13 and form abnormal branches, instead of forming their wild type axonal extensions onto the muscle fibers. These aberrant branches wander over the prospective target muscles and occasionally form connections at ectopic sites. Mutants do not establish the three branched terminal arbor on muscles 7, 6, 13 and 12. The transverse nerve is often incomplete and invades the ventral muscle field. A few muscles (3, 5, 11, 20) show variably penetrant defects in their attachment to the epidermis, and variable defects in the location of their attachments. Severe wing venation defect when transheterozygous with ab⁹⁴. Wing veins of ab¹/ab^1D heterozygous adults are absent between the margin and the posterior crossvein. Thoracic and wing mechanosensory bristles are missing. Occasionally one of the campaniform sense organs on wing vein L3 is absent. Legs are gnarled and the more distal segments are reduced in length or absent; male genitalia rotated.

(Hu et al., 1995)

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

ab[+]/ab^1D is a suppressor | partially of some die during P-stage phenotype of mir-125^KO.C, mir-let7^KO.C

(Caygill and Johnston, 2008)

ab¹/ab^1D is a suppressor | partially of some die during P-stage phenotype of mir-125^KO.C, mir-let7^KO.C

(Caygill and Johnston, 2008)

Phenotype Manifest In

Suppressor of

Statement

Reference

ab[+]/ab^1D is a suppressor | partially of border follicle cell phenotype of EcR^{B1-ΔC655.F645A.UAS}, Scer\GAL4^slbo.2.6

(Jang et al., 2009)

ab[+]/ab^1D is a suppressor | partially of NMJ bouton | pupal stage phenotype of mir-125^KO.C, mir-let7^KO.C

(Caygill and Johnston, 2008)

Additional Comments

Genetic Interactions

Statement

Reference

The presence of ab^1D/+ reduces the frequency of incomplete border migration in animals expressing EcR^{B1-ΔC655.F645A.Scer\UAS} under the control of Scer\GAL4^slbo.2.6 to 34% of stage 10 egg chambers.

(Jang et al., 2009)

The reduction in bouton number at the NMJ that is seen in let-7^KO.C mir-125^KO.C double mutant animals at 96 hours APF is significantly rescued by ab^1D/+.

(Caygill and Johnston, 2008)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

9586

w^*; P{lwB}ab^1D/CyO

Notes on Origin

Discoverer

Comments

Comments

Alleles fall into an allelic series with respect to wing venation and bristle defects: ab¹/ab¹ = ab⁹⁴/ab⁹⁴ < ab¹/ab^60M = ab¹/ab^G9 < ab¹/ab^1D = ab¹/ab^G5.

(Hu et al., 1995)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

ab^1D

(Preger-Ben Noon et al., 2016, Garaulet et al., 2014, Turkel et al., 2013, Kucherenko et al., 2012, Jang et al., 2009, Caygill and Johnston, 2008)

Name Synonyms

Secondary FlyBase IDs

References (7)

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