FlyBase Allele Report: Dmel\aub[N11]

General Information

Symbol

Dmel\aub^N11

Species

D. melanogaster

Name

FlyBase ID

FBal0049313

Feature type

allele

Associated gene

Dmel\aub

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Wilson et al., 1996)

Progenitor genotype

Cytology

Description

As a result of the deletion the frame is changed after E740.

(Harris, 2005.5.26)

154bp deletion, resulting in a frameshift which is predicted to add 16 novel amino acids after residue 740. Nucleotide substitution: G5549A (silent polymorphism).

(Harris and Macdonald, 2001)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

2L:10,998,158..10,998,311 [-]

Comment:

Location of a 154bp deletion beginning in codon G741, which leads to a frameshift and early translation termination. The resulting predicted protein has 16 novel amino acids added after residue 740.

(Harris, 2005.5.26, Harris and Macdonald, 2001)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal mitotic cell cycle | female (with aub^HN2)

(Pek and Kai, 2011)

lethal | maternal effect | recessive

(Wilson et al., 1996)

Phenotype Manifest In

cystoblast (with aub^HN2)

(Pek and Kai, 2011)

embryo | maternal effect | posterior

(Wilson et al., 1996)

embryonic/larval cuticle | embryonic stage (with aub^QC42)

(Rouget et al., 2010)

embryonic/larval cuticle | embryonic stage | maternal effect (with aub^HN2)

(Rouget et al., 2010)

female germline stem cell (with aub^HN2)

(Pek and Kai, 2011)

Detailed Description

Statement

Reference

Germline stem cells and cystoblasts of aub^N11/aub^HN ovaries show delays in prometaphase and chromosome segregation defects.

(Pek and Kai, 2011)

No embryos derived from aub^N11/aub^HN2 females produce a cuticle.

No embryos derived from aub^N11/aub^QC42 females produce a cuticle.

(Rouget et al., 2010)

2% of eggs from homozygous mothers are fertilized and embryos lack abdominal segments and pole cells, i.e. show a classic posterior group mutant phenotype.

(Wilson et al., 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

aub[+]/aub^N11 is an enhancer of abnormal meiotic cell cycle phenotype of RanGAP^Sd

(Gell and Reenan, 2013)

NOT Suppressor of

Statement

Reference

aub^HN2/aub^N11 is a non-suppressor of abnormal eye color phenotype of w^RNAi.GMR

(Pelisson et al., 2007)

Phenotype Manifest In

Suppressor of

Statement

Reference

aub^HN2/aub^N11 is a suppressor of primordial germ cell | ectopic phenotype of osk^short.bcd

(Harris and Macdonald, 2001)

aub^N11 is a suppressor of phenotype of osk^{bcd.3UTR.Tag:polyHis}

(Wilson et al., 1996, Wilson et al., 1996)

NOT Suppressor of

Statement

Reference

aub^HN2/aub^N11 is a non-suppressor of eye phenotype of w^RNAi.GMR

(Pelisson et al., 2007)

Additional Comments

Genetic Interactions

Statement

Reference

The segregation distortion seen in males carrying either the SD-5 or SD-Mad-ltcn Dp(2;2)RanGAP^SD chromosome variant is enhanced (the k[[c]] value, or proportion of Dp(2;2)RanGAP^SD-bearing progeny as the fraction of total progeny (corrected for viability), is significantly increased) if the males are also carrying a single copy of aub^N11.

(Gell and Reenan, 2013)

The yellowish eye colour caused by expression of one copy of w^dsRNA.GMR in a wild-type background is not altered if the flies are also carrying aub^HN2/aub^N11.

(Pelisson et al., 2007)

Ectopic pole cells are not produced at the anterior of embryos derived from aub^N11/aub^HN ; osk^short.bcd females.

(Harris and Macdonald, 2001)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 4 )

Crossreferences

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

aub^N11

(Iki et al., 2023, Wang et al., 2020, Patil et al., 2014, Gell and Reenan, 2013, Anand and Kai, 2012, Kelleher et al., 2012, Pöyhönen et al., 2012, Pek and Kai, 2011, Pek and Kai, 2011, Creed et al., 2010, Patil and Kai, 2010, Rouget et al., 2010, Lim et al., 2009, Pek et al., 2009, Anne et al., 2007, Josse et al., 2007, Lim and Kai, 2007, Lim and Kai, 2007, Pelisson et al., 2007)

Name Synonyms

Secondary FlyBase IDs

References (26)

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