FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\dmtI184
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General Information
Symbol
Dmel\dmtI184
Species
D. melanogaster
Name
FlyBase ID
FBal0049410
Feature type
allele
Associated gene
Dmel\dmt
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Salzberg et al., 1994)
Mutagen
ethyl methanesulfonate
(Salzberg et al., 1994)
Progenitor genotype
Cytology
Description

Amino acid replacement: Q319term.

(Kerman and Andrew, 2010)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:9,712,223..9,712,223 [+]
Nucleotide change:

C9712223T

Amino acid change:

Q319term | dmt-PA

Reported amino acid change:

Q319term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Kerman and Andrew, 2010)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous dmtI184 mutant embryos exhibit frequent breaks and/or gaps in the dorsal trunk, often associated with shorter ventral tracheal branches. Individual salivary ducts often have significant gaps or are completely missing.

      dmt3999/dmtI184 mutant embryos exhibit frequent breaks and/or gaps in the dorsal trunk, often associated with shorter ventral tracheal branches. Individual salivary ducts often have significant gaps or are completely missing. Defects are also seen in the peripheral nervous system.

      dmt589/dmtI184 mutant embryos exhibit frequent breaks and/or gaps in the dorsal trunk, often associated with shorter ventral tracheal branches. Individual salivary ducts often have significant gaps or are completely missing.

      Global inhibition of apoptosis in dmtI184 mutant embryos by Df(3L)H99 rescues tracheal, salivary duct and peripheral nervous system defects. The number of dorsal trunks and individual ducts with gaps is significantly reduced, the ventral tracheal branches are longer and the peripheral nervous system is more organised.

      (Kerman and Andrew, 2010)

      Defect in embryonic PNS development: PNS is disorganised and exhibits loss of neurons.

      (Salzberg et al., 1994)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Complements: knkex59.

      (Beitel and Krasnow, 2000)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      dalmI84
      dalmatianI84
      (Beitel and Krasnow, 2000)
      dmt1184
      (Prokopenko et al., 2000)
      dmtI184
      (Kerman and Andrew, 2010)
      dmtl184
      (Ribeiro et al., 2016)
      Name Synonyms
      Secondary FlyBase IDs
      • FBal0118272
      References (6)