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FB2021_04, released August 17, 2021

Gene: Dmel\dmt

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General Information
Symbol
Dmel\dmt
Species
D. melanogaster
Name
dalmatian
Annotation Symbol
CG8374
Feature Type
protein_coding_gene
FlyBase ID
FBgn0278604
Gene Model Status
Current
Stock Availability
7 publicly available
Gene Summary
dalmatian (dmt) encodes a nuclear protein that localizes to centromeric heterochromatin and other polytene chromosome bands. It is required to block expression of rpr and hid during the radiation resistant stage of embryonic development, when cells become irreversibly committed to cell fate. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)
All Summaries
Also Known As

aul

Key Links
Genomic Location
Cytogenetic map
85E5-85E5
Sequence location
3R:9,711,142..9,714,675 [+]
Recombination map
3-49
RefSeq locus
NT_033777 REGION:9711142..9714675
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (10 terms)
Molecular Function (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (8 terms)
Terms Based on Experimental Evidence (7 terms)
CV Term
Evidence
References
involved_in cellular response to radiation
inferred from mutant phenotype
(Kerman and Andrew, 2010)
involved_in mitotic sister chromatid cohesion
inferred from mutant phenotype
(Nishiyama et al., 2010)
involved_in nervous system development
inferred from mutant phenotype
(Koizumi et al., 2007)
involved_in primary branching, open tracheal system
inferred from mutant phenotype
(Myat et al., 2005)
involved_in salivary gland development
inferred from mutant phenotype
(Kerman and Andrew, 2010)
involved_in trachea development
inferred from mutant phenotype
(Kerman and Andrew, 2010)
NOT involved_in mitotic spindle assembly checkpoint signaling
inferred from mutant phenotype
(assigned by UniProt )
(Nishiyama et al., 2010)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in peripheral nervous system development
traceable author statement
(Salzberg et al., 1994)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
located_in chromatin
inferred from direct assay
(Goshima et al., 2007)
located_in heterochromatin
inferred from direct assay
(Kerman and Andrew, 2010)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
dalmatian (dmt) encodes a nuclear protein that localizes to centromeric heterochromatin and other polytene chromosome bands. It is required to block expression of rpr and hid during the radiation resistant stage of embryonic development, when cells become irreversibly committed to cell fate. [Date last reviewed: 2019-03-07]
Protein Function (UniProtKB)
Regulator of sister chromatid cohesion in mitosis. Probably involved in development of the central nervous system.
(UniProt, Q9VH89)
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\dmt for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.49

Gene model reviewed during 5.39

Sequence Ontology: Class of Gene
gene
(Myat et al., 2005)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
dmt-RA
FBtr0082086
NM_079571
3190
857
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
dmt-PA
FBpp0081564
96.5
857
10.02
NP_524295
AAF54430
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\dmt using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in chromatin
inferred from direct assay
(Goshima et al., 2007)
located_in heterochromatin
inferred from direct assay
(Kerman and Andrew, 2010)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\dmt in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB
EMBL-EBI Single Cell Expression Atlas
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 10 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of dmt
Transgenic constructs containing regulatory region of dmt
Aberrations (Deficiencies and Duplications) ( 5 )
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal (with Df(3R)by62)
lethal | recessive
lethal - all die before end of P-stage | recessive
partially lethal - majority die, with Scer\GAL4pnr-MD237
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
Other Phenotypes
Allele
increased cell death | embryonic stage 12
increased cell death | embryonic stage 13
increased cell death | embryonic stage 14
some die during pharate adult stage | recessive
some die during pupal stage, with Scer\GAL4pnr-MD237
visible, with Scer\GAL4pnr-MD237
Phenotype manifest in
Allele
dorsal trunk primordium
dorsal trunk primordium (with Df(3R)GB104)
dorsal trunk primordium (with dmt589)
dorsal trunk primordium (with dmt3999)
dorsal trunk primordium (with dmtI184)
embryonic/larval trachea
embryonic/larval trachea (with Df(3R)GB104)
embryonic/larval trachea (with dmt589)
embryonic/larval trachea (with dmt3999)
embryonic/larval trachea (with dmtI184)
embryonic/larval trachea | embryonic stage 12
embryonic/larval trachea | embryonic stage 13
embryonic/larval trachea | embryonic stage 14
embryonic salivary gland duct
embryonic salivary gland duct (with Df(3R)GB104)
embryonic salivary gland duct (with dmt589)
embryonic salivary gland duct (with dmt3999)
embryonic salivary gland duct (with dmtI184)
mesothoracic tergum, with Scer\GAL4pnr-MD237
neuron & peripheral nervous system
neuron | embryonic stage
peripheral nervous system
presumptive embryonic/larval tracheal system
tracheal system
trichogen cell, with Scer\GAL4pnr-MD237
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (0)
No records found.
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (0)
No records found.
Rattus norvegicus (Norway rat) (0)
No records found.
Xenopus tropicalis (Western clawed frog) (0)
No records found.
Danio rerio (Zebrafish) (0)
No records found.
Caenorhabditis elegans (Nematode, roundworm) (0)
No records found.
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190DX9 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00009418
Drosophila simulans
Dsim\GD18640
Drosophila sechellia
Dsec\GM23829
Drosophila erecta
Dere\GG10947
Drosophila erecta
Dere\GG17048
Drosophila erecta
Dere\GG10946
Drosophila yakuba
Dyak\GE25977
Drosophila ananassae
Dana\GF11681
Drosophila pseudoobscura pseudoobscura
Dpse\GA21029
Drosophila persimilis
Dper\GL27168
Drosophila willistoni
Dwil\GK12107
Drosophila virilis
Dvir\GJ14448
Drosophila mojavensis
Dmoj\GI10842
Drosophila grimshawi
Dgri\GH18992
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500UD )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17007672
Glossina morsitans
Tsetse fly
Gmor\GMOY007479
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_05237
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( None identified )
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( None identified )
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
No non-Arthropod Metazoa orthologies identified
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (0)
No records found.
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    Summary of Genetic Interactions
    esyN Network Diagram
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    External Data
    Linkouts
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3R
    Recombination map
    3-49
    Cytogenetic map
    85E5-85E5
    Sequence location
    3R:9,711,142..9,714,675 [+]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    85E5-85E5
    Limits computationally determined from genome sequence between P{EP}CrcEP3006 and P{lacW}s2681
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    85D11-85F6
    (Myat et al., 2005)
    Determined by deficiency mapping.
    (Myat et al., 2005)
    85E5-85E11
    (Prokopenko, 1999.8.3, Prokopenko, 1999.11.10)
    85E6-85E10
    (determined by in situ hybridisation)
    (Szeged Stock Center, 1998-, Deak et al., 1997)
    85E5-85E11
    (determined by in situ hybridisation)
    (Salzberg et al., 1997)
    85E1-85F1
    (determined by in situ hybridisation)
    (Salzberg et al., 1994)
    Experimentally Determined Recombination Data
    Location

    3-49

    (FlyBase, 2016)

    3-46.2

    (Comeron et al., 2012)

    3-49.5--52

    (Salzberg et al., 1994)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (7)
    Genomic Clones (14)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (26)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      Antibody Information
      Laboratory Generated Antibodies
       

      polyclonal

      (Kerman and Andrew, 2010)
      Commercially Available Antibodies
       
      Other Information
      Relationship to Other Genes
      Source for database identify of
      Source for database merge of

      Source for merge of: dmt anon-WO0118547.317

      (FlyBase, 1996-)

      Source for merge of: aul dmt

      (Kerman and Andrew, 2010)
      Additional comments

      snoRNA:dmt-a is encoded in an intron of dmt.

      (Graveley et al., 2011)

      Source for merge of dmt anon-WO0118547.317 was sequence comparison ( date:051113 ).

      (FlyBase, 1996-)
      Other Comments

      RNAi screen using dsRNA made from templates generated with primers directed against this gene results in chromosome misalignment on the metaphase spindle when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA.

      (Goshima et al., 2007)

      Area matching Drosophila EST AA441018.

      (Davies, 2001.3.15)

      dmt is required for PNS development in the embryo.

      (Salzberg et al., 1994)
      Origin and Etymology
      Discoverer
      Etymology
      Identification
      External Crossreferences and Linkouts ( 30 )
      Sequence Crossreferences
      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
      UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
      Other crossreferences
      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
      DRscDB
      EMBL-EBI Single Cell Expression Atlas
      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      InterPro - A database of protein families, domains and functional sites
      KEGG Genes - Molecular building blocks of life in the genomic space.
      MARRVEL_MODEL
      Linkouts
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Synonyms and Secondary IDs (10)
      Datasets (0)
      Study focus (0)
      Experimental Role
      Project
      Project Type
      Title
      References (51)