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General Information
Symbol
Dmel\dmtI184
Species
D. melanogaster
Name
FlyBase ID
FBal0049410
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

C9712223T

Amino acid change:

Q319term | dmt-PA

Reported amino acid change:

Q319term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: Q319term.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygous dmtI184 mutant embryos exhibit frequent breaks and/or gaps in the dorsal trunk, often associated with shorter ventral tracheal branches. Individual salivary ducts often have significant gaps or are completely missing.

dmt3999/dmtI184 mutant embryos exhibit frequent breaks and/or gaps in the dorsal trunk, often associated with shorter ventral tracheal branches. Individual salivary ducts often have significant gaps or are completely missing. Defects are also seen in the peripheral nervous system.

dmt589/dmtI184 mutant embryos exhibit frequent breaks and/or gaps in the dorsal trunk, often associated with shorter ventral tracheal branches. Individual salivary ducts often have significant gaps or are completely missing.

Global inhibition of apoptosis in dmtI184 mutant embryos by Df(3L)H99 rescues tracheal, salivary duct and peripheral nervous system defects. The number of dorsal trunks and individual ducts with gaps is significantly reduced, the ventral tracheal branches are longer and the peripheral nervous system is more organised.

Defect in embryonic PNS development: PNS is disorganised and exhibits loss of neurons.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
Comments
Comments
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
  • FBal0118272
References (6)