FlyBase Allele Report: Dmel\dpp[BP.hs]

General Information

Symbol

Dmel\dpp^BP.hs

Species

D. melanogaster

Name

FlyBase ID

FBal0049436

Feature type

allele

Associated gene

Dmel\dpp

Associated Insertion(s)

Carried in Construct

P{hs-dpp.BP}

Also Known As

hs-dpp

Key Links

Transgenic product class

cDNA

(Twombly et al., 1996)

wild_type

(Twombly et al., 1996)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Twombly et al., 1996)

wild_type

(Twombly et al., 1996)

Mutagen

in vitro construct

(Gajewski et al., 1998, Twombly et al., 1996, Mathies et al., 1994)

Progenitor genotype

Carried in construct

P{hs-dpp.BP}

Cytology

Description

The dpp cDNA E55 (FBrf0047083) is flanked by dpp 3' sequences extending beyond the polyadenylation site, and expressed from an Hsp70 promoter.

(Twombly et al., 1996)

Allele components

Component

Use(s)

Regulatory region(s)

Hsp70

Encoded product / tool

dpp

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | heat sensitive

(Yu et al., 1996)

visible | heat sensitive

(Yu et al., 1996)

Phenotype Manifest In

Detailed Description

Statement

Reference

In mutant heat shocked wing discs, cytonemes project outwards in all directions from examined cells. This contrasts with wild-type where cytonemes only project towards the anterior posterior or dorsal ventral axes. These cytonemes are significantly shorter than those seen in wild-type, averaging 10.6μm in length. Cells in the hinge domain, which normally do not extend cytonemes, extend them in apparently random directions.

(Hsiung et al., 2005)

Animals with 8 copies of P{hs-dpp.BP} show an increase in single germ-cell numbers per germarium after heat shock.

(Gilboa et al., 2003)

Heat induction of dpp expression during a broad period of oogenesis leads to dorsalization of the embryonic cuticle. A high percentage of eggs from these females remain unfertilized. Overexpression during stage 10 leads to defects in patterning in the AP axis of egg shell structures.

(Araujo and Bier, 2000)

In dpp^BP.hs; CrebA^wR7 larvae the entire cuticle is lateralised.

(Andrew et al., 1997)

Ectopic dpp expression causes the formation of egg chambers containing multiplicity of 16 germ-line cells, which may be caused by the enveloping of two or more germ-line cysts by invaginating follicle cells into a single egg chamber.

(Forbes et al., 1996)

58% of females carrying eight copies of dpp^BP.hs show vastly enlarged opercula, and nearly all have abnormal dorsal appendages, indicative of expanded anterior eggshell domains.

(Twombly et al., 1996)

Heat induced expression during larval or pre-pupal stages has little effect on wing venation. Heat shocks delivered between 16 and 28 hours cause severe ectopic vein phenotype and between 28 and 40 hours blister phenotype. Heat shocks administered after 44 hours have no effect.

(Yu et al., 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressed by

Statement

Reference

dpp^BP.hs has germline stem cell | increased number phenotype, suppressible by zpg^unspecified/zpg^unspecified

(Gilboa et al., 2003)

Suppressor of

Statement

Reference

dpp^BP.hs is a suppressor | heat sensitive | maternal effect | partially of embryonic epidermis phenotype of Dp(2;1)G146, Tl³

(Araujo and Bier, 2000)

Additional Comments

Genetic Interactions

Statement

Reference

The increase in single germ-cell numbers per germarium of 8xP{hs-dpp.BP} animals after heat shock is suppressed by zpg^unspecified/zpg^unspecified.

(Gilboa et al., 2003)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

dpp^BP.hs

dpp^hs.P-BP

(Twombly et al., 1996)

dpp^hs.PP

Name Synonyms

Secondary FlyBase IDs

FBal0039278

References (19)

Report Sections

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