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General Information
Symbol
Dmel\dppBP.hs
Species
D. melanogaster
Name
FlyBase ID
FBal0049436
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
hs-dpp
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

The dpp cDNA E55 (FBrf0047083) is flanked by dpp 3' sequences extending beyond the polyadenylation site, and expressed from an Hsp70 promoter.

Allele components
Product class / Tool use(s)
Regulatory region(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

In mutant heat shocked wing discs, cytonemes project outwards in all directions from examined cells. This contrasts with wild-type where cytonemes only project towards the anterior posterior or dorsal ventral axes. These cytonemes are significantly shorter than those seen in wild-type, averaging 10.6μm in length. Cells in the hinge domain, which normally do not extend cytonemes, extend them in apparently random directions.

Animals with 8 copies of P{hs-dpp.BP} show an increase in single germ-cell numbers per germarium after heat shock.

Heat induction of dpp expression during a broad period of oogenesis leads to dorsalization of the embryonic cuticle. A high percentage of eggs from these females remain unfertilized. Overexpression during stage 10 leads to defects in patterning in the AP axis of egg shell structures.

In dppBP.hs; CrebAwR7 larvae the entire cuticle is lateralised.

Ectopic dpp expression causes the formation of egg chambers containing multiplicity of 16 germ-line cells, which may be caused by the enveloping of two or more germ-line cysts by invaginating follicle cells into a single egg chamber.

58% of females carrying eight copies of dppBP.hs show vastly enlarged opercula, and nearly all have abnormal dorsal appendages, indicative of expanded anterior eggshell domains.

Heat induced expression during larval or pre-pupal stages has little effect on wing venation. Heat shocks delivered between 16 and 28 hours cause severe ectopic vein phenotype and between 28 and 40 hours blister phenotype. Heat shocks administered after 44 hours have no effect.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressed by
Suppressor of
Additional Comments
Genetic Interactions
Statement
Reference

The increase in single germ-cell numbers per germarium of 8xP{hs-dpp.BP} animals after heat shock is suppressed by zpgunspecified/zpgunspecified.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
dppBP.hs
dpphs.PP
Name Synonyms
Secondary FlyBase IDs
  • FBal0039278
References (18)