FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\grauRM61
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General Information
Symbol
Dmel\grauRM61
Species
D. melanogaster
Name
FlyBase ID
FBal0049603
Feature type
allele
Associated gene
Dmel\grau
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Lieberfarb et al., 1996, Page and Orr-Weaver, 1996, Schupbach and Wieschaus, 1989)
Progenitor genotype
Cytology
Description

Amino acid replacement: Q36term.

(Chen et al., 2000)

Nucleotide substitution: C158T.

(Chen et al., 2000)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:21,011,740..21,011,740 [-]
Nucleotide change:

C21011740T

Reported nucleotide change:

C158T

Amino acid change:

Q36term | grau-PA

Reported amino acid change:

Q36term

(Chen et al., 2000)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Eggs laid by grauQQ36/grauRM61 females typically arrest with two spindles at metaphase II of meiosis.

      (Whitfield et al., 2013)

      A small percentage of embryos laid by grauRM61/Df(2R)Pu-D17 females develop into adult flies.

      (Chen et al., 2000)

      Embryos have a block in oocyte meiosis.

      (Lieberfarb et al., 1996)

      Females lay eggs that arrest in meiosis II, the earliest defect is in anaphase I. Premature sister chromatid separation does not rescue the meiotic defects, as shown in mei-S3321 double mutants. Male meiosis and mitosis are normal.

      (Page and Orr-Weaver, 1996)

      Eggs derived from homozygous females initiate development and cytoplasmic clearing occurs in a narrow zone around the egg periphery (in wild-type embryos this process is coupled to the arrival of the nuclei at the periphery). The eggs do not seem to develop beyond this stage; pole cells are not formed and cellularisation does not occur. However, about two hours after cytoplasmic clearing, the egg periphery starts to show local contractions, in what might be an attempt at gastrulation. These contractions eventually lead to eggs which typically have one or two condensed yolk balls surrounded by more transparent cytoplasm.

      (Schupbach and Wieschaus, 1989)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      grauRM61/Df(2R)Pu-D17 has lethal | maternal effect phenotype, enhanceable by cortQW55/cort[+]

      (Chen et al., 2000)

      grauRM61/Df(2R)Pu-D17 has lethal | maternal effect phenotype, enhanceable by cortRH65/cort[+]

      (Chen et al., 2000)
      Suppressed by
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The meiotic arrest phenotype seen in eggs laid by grauQQ36/grauRM61 females is partially suppressed if the females also carry mtrm126/+.

      (Whitfield et al., 2013)

      The small percentage of developing embryos laid by grauRM61/Df(2R)Pu-D17 females is abolished if the females are also heterozygous for cortQW55 or cortRH65.

      (Chen et al., 2000)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      grauRM61
      (Whitfield et al., 2013)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)