FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\grhB37
Open Close
General Information
Symbol
Dmel\grhB37
Species
D. melanogaster
Name
FlyBase ID
FBal0049607
Feature type
allele
Associated gene
Dmel\grh
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Cenci and Gould, 2005)
Mutagen
ethyl methanesulfonate
(Bray and Kafatos, 1991)
Progenitor genotype
Cytology
Description

Deletion of 7bp within the coding region which causes a frameshift. The resulting protein is truncated.

(Bray and Kafatos, 1991)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
2R:17,839,421..17,839,429 [+]
Comment:

Deletion of the first six bases and the ninth base of this region in grhB37 leads to a frameshift and early termination of the protein. Position of mutation on reference sequence inferred by FlyBase curator.

(Bray and Kafatos, 1991)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      grhB37/grh370 mutants do not have surviving doublesex-expressing larval terminal neuroblasts in the terminal region of the female third instar larval ventral nerve cord, similar to controls.

      (Ghosh et al., 2019)

      Thoracic grhB37 clones contain less neurons than wild-type clones and the neuroblast ceases mitosis by 72 hours and is no longer evident by 96 hours.

      (Cenci and Gould, 2005)

      Homozygous or grhB37/Df(2R)Pcl7B embryos die at the end of embryogenesis. Segmentation appears normal, but the head skeleton has an abnormal granular appearance. Cuticle formation is also abnormal; embryos removed from the vitelline membrane appear flaccid and ameoboid. The mouth hooks and denticles are poorly differentiated, and the denticles are frequently disordered. The tracheal network also appears abnormal.

      (Bray and Kafatos, 1991)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      grhB37 has larval thorax & neuroblast | somatic clone phenotype, suppressible by Scer\GAL4elav-C155/BacA\p35UAS.cHa

      (Cenci and Gould, 2005)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Suppression of apoptosis in grhB37 clones, achieved by expression of BacA\p35Scer\UAS.cHa driven by Scer\GAL4elav-C155, results in the continued presence of the neuroblast at 96 hours in over 40% of cases. However, this rescued neuroblast is often larger in size than wild-type clones.

      (Cenci and Gould, 2005)
      Xenogenetic Interactions
      Statement
      Reference

      Suppression of apoptosis in grhB37 clones, achieved by expression of BacA\p35Scer\UAS.cHa driven by Scer\GAL4elav-C155, results in the continued presence of the neuroblast at 96 hours in over 40% of cases. However, this rescued neuroblast is often larger in size than wild-type clones.

      (Cenci and Gould, 2005)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      May be a weaker allele than grhB32.

      (Liaw et al., 1995)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      References (20)