FlyBase Allele Report: Dmel\shg[R64a]

General Information

Symbol

Dmel\shg^R64a

Species

D. melanogaster

Name

FlyBase ID

FBal0050501

Feature type

allele

Associated gene

Dmel\shg

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - genetic evidence

loss of function allele

Mutagen

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Tepass et al., 1996)

loss of function allele

(Takahashi et al., 2005)

Mutagen

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die during embryonic stage | recessive

(Tepass et al., 1996)

some die during embryonic stage | recessive

(Tepass et al., 1996)

Phenotype Manifest In

egg | germline clone

(Tepass et al., 1996)

embryonic epidermis & embryonic head

(Tepass et al., 1996)

embryonic ventral epidermis

(Tepass et al., 1996)

gonad | embryonic stage (with shg²)

(Weyers et al., 2011)

ovary | germline clone

(Tepass et al., 1996)

Detailed Description

Statement

Reference

shg^R64a/shg² embryos have abnormal gonads that exhibit both somatic gonadal precursor cluster fusion defects and compaction defects.

(Weyers et al., 2011)

Class III allele: lacks most of the head and ventral epidermis. In germ-line clones, no eggs are recovered.

(Tepass et al., 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhancer of

Statement

Reference

shg[+]/shg^R64a is an enhancer of eye phenotype of Src42A^KR.hs.2sev

(Takahashi et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

Epidermal cells expressing Rab11^{S25N.Scer\UAS} under the control of Scer\GAL4^en-e16E in a shg^R64a background do not elongate during dorsal closure stages and detach from the amnioserosa. The embryos have very large dorsal holes and have lateral holes in the cuticle.

(Mateus et al., 2011)

The Src42A^KR.hs.2sev/+ eye phenotype is enhanced when flies are also heterozygous for shg^R64a.

(Takahashi et al., 2005)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

shg^E7A-1

(Takahashi et al., 2005)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

shg^R64

(Mateus et al., 2011)

shg^R64a

(Banach-Latapy et al., 2023, Weyers et al., 2011)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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