FlyBase Allele Report: Dmel\nanos[nanos.+2.Hsp83]

General Information

Symbol

Dmel\nanos^{nanos.+2.Hsp83}

Species

D. melanogaster

Name

FlyBase ID

FBal0051320

Feature type

allele

Associated gene

Dmel\nanos

Associated Insertion(s)

Carried in Construct

P{nanos-tub:nanos+2}

Also Known As

nos-tub:nos+2

Key Links

Transgenic product class

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

Mutagen

in vitro construct

(Gavis et al., 1996)

Progenitor genotype

nanos^{αTub84B.UTR.Tag:HA}

(Gavis et al., 1996)

Carried in construct

P{nanos-tub:nanos+2}

Cytology

Description

nos 3' UTR fragment consists of nucleotide 6 to 185.

(Gavis et al., 1996)

Allele components

Component

Use(s)

Encoded product / tool

nanos

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

wild-type

(Crucs et al., 2000, Bergsten and Gavis, 1999)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

The ability of nos^nos.+2.Hsp83 to rescue abdominal segmentation of nos^BN embryos is severely compromised in a rump¹/Df(3R)by416 background; more than 90% of the embryos develop fewer than 4 abdominal segments.

(Jain and Gavis, 2008)

Embryos derived from vas¹/vas³ females carrying nos^nos.+2.Hsp83 do not produce any abdominal segments.

(Bergsten and Gavis, 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

nanos^{nanos.+2.Hsp83} rescues nanos^BN

(Crucs et al., 2000)

nanos^{nanos.+2.Hsp83} rescues nanos^BN

(Bergsten and Gavis, 1999)

Partially rescues

nanos^{nanos.+2.Hsp83} partially rescues nanos^BN

(Jain and Gavis, 2008)

Comments

Embryos derived from nos^BN females carrying nos^nos.+2.Hsp83 develop well demarcated gonads containing morphologically normal germ cells. Female adults that develop from these embryos show similar egg production to age matched controls.

(Gavis et al., 2008)

nos^nos.+2.Hsp83 partially rescues the abdominal defects of nos^BN embryos, such that most develop 4 or more abdominal segments and over 30% are nearly wild type, with 7 to 8 segments.

(Jain and Gavis, 2008)

nos^nos.+2.Hsp83 rescues the abdominal segmentation defect of embryos derived from nos^BN females; 2% of embryos have 4-6 abdominal segments and 98% have 7-8 abdominal segments.

(Crucs et al., 2000)

98% of embryos derived from nos^BN females carrying nos^nos.+2.Hsp83 develop wild-type anterior structures and 7-8 abdominal segments.

(Bergsten and Gavis, 1999)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

nanos^{nanos.+2.Hsp83}

nanos^nos.+2.Hsp83

nos^nos.+2.Hsp83

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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