FlyBase Allele Report: Dmel\Sxl[cF1.otu]

General Information

Symbol

Dmel\Sxl^cF1.otu

Species

D. melanogaster

Name

FlyBase ID

FBal0051862

Feature type

allele

Associated gene

Dmel\Sxl

Associated Insertion(s)

Carried in Construct

P{otu-Sxl.cF1}

Also Known As

P{otu::SxlcDNA}

Key Links

Transgenic product class

cDNA

(Hager and Cline, 1997)

wild_type

(Hager and Cline, 1997)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Hager and Cline, 1997)

wild_type

(Hager and Cline, 1997)

Mutagen

in vitro construct

(Hager and Cline, 1997, Salz and Flickinger, 1996)

Progenitor genotype

Carried in construct

P{otu-Sxl.cF1}

Cytology

Description

578bp NotI-Asp718 fragment of the otu drives expression of the 1.8kb female Sxl cDNA, cF1.

(Hager and Cline, 1997)

Allele components

Component

Use(s)

Regulatory region(s)

otu

Encoded product / tool

Sxl

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates germ cell cancer

modeled by snf¹⁴⁸

(Chau et al., 2009)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

male fertile

(Hager and Cline, 1997)

viable | male

(Hager and Cline, 1997)

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression generates testes displaying autoregulatory cysts.

(Hager and Cline, 1997)

P{otu-Sxl.cF1} suppresses snf's female lethal-synergistic interaction phenotype.

(Salz and Flickinger, 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Sxl^cF1.otu is a suppressor of decreased cell number | oogenesis phenotype of snf¹⁴⁸

(Mercer et al., 2025)

Sxl^cF1.otu is a suppressor of female sterile phenotype of snf¹

(Gawande et al., 2006, Hager and Cline, 1997)

Sxl^cF1.otu is a suppressor of female sterile phenotype of snf¹⁴⁸

(Gawande et al., 2006, Nagengast et al., 2003)

NOT Suppressor of

Statement

Reference

Sxl^cF1.otu is a non-suppressor of decreased cell number | oogenesis phenotype of bbn^KO

(Mercer et al., 2025)

Other

Statement

Reference

Sxl^cF1.otu, Sxl^fP7B0, snf¹⁴⁸ has lethal phenotype

(Nagengast et al., 2003)

Sxl^fP7B0/Sxl^cF1.otu, snf¹⁴⁸ has lethal phenotype

(Nagengast et al., 2003)

Phenotype Manifest In

Suppressor of

Statement

Reference

Sxl^cF1.otu is a suppressor of ovariole phenotype of snf¹⁴⁸

(Mercer et al., 2025)

Sxl^cF1.otu is a suppressor of female germline cell phenotype of snf¹⁴⁸

(Mercer et al., 2025)

NOT Suppressor of

Statement

Reference

Sxl^cF1.otu is a non-suppressor of ovariole phenotype of bbn^KO

(Mercer et al., 2025)

Sxl^cF1.otu is a non-suppressor of female germline cell | decreased number phenotype of bbn^KO

(Mercer et al., 2025)

Additional Comments

Genetic Interactions

Statement

Reference

If snf¹⁴⁸/snf¹⁴⁸, Sxl^cF1.otu females are crossed with Sxl^fP7B0 males only 6% of her Sxl^fP7B0/+ daughters survive.

(Nagengast et al., 2003)

Expression suppresses the germline-autonomous female sterility of snf¹ mutants.

(Hager and Cline, 1997)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

58491

y¹ w¹ snf¹ sn³; P{otu-Sxl.cF1}A

Notes on Origin

Discoverer

Comments

Ectopic Sxl protein triggers the female-specific Sxl RNA splicing feedback loop in male germ cells without disrupting spermatogenesis. Protein is also found in somatic tissue but it is irrelevant in generating autoregulatory germline cysts.

(Hager and Cline, 1997)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Sxl^cF1.otu

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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