FlyBase Allele Report: Dmel\bbn[KO]

General Information

Symbol

Dmel\bbn^KO

Species

D. melanogaster

Name

FlyBase ID

FBal0408341

Feature type

allele

Associated gene

Dmel\bbn

Associated Insertion(s)

TI{TI}bbn^KO

Carried in Construct

Key Links

Allele class

amorphic allele - molecular evidence

Mutagen

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Mercer et al., 2025)

Mutagen

CRISPR/Cas9

(Mercer et al., 2025)

gene targeting by homologous recombination

(Mercer et al., 2025)

Progenitor genotype

Associated Insertion(s)

TI{TI}bbn^KO

Cytology

Description

The bbn coding sequence has been deleted and replaced by a loxP cassette that contains a Disc\RFP^{DsRed(T1).3xP3.cHa} marker.

(Mercer et al., 2025)

Allele components

Component

Use(s)

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased cell number | oogenesis

(Mercer et al., 2025)

decreased fecundity | female

(Mercer et al., 2025)

female sterile

(Mercer et al., 2025)

female sterile (with bbn^C-HA)

(Mercer et al., 2025)

male fertile

(Mercer et al., 2025)

viable

(Mercer et al., 2025)

Phenotype Manifest In

egg chamber (with bbn^N-HA)

(Mercer et al., 2025)

female germline cell | decreased number

(Mercer et al., 2025)

nurse cell (with bbn^N-HA)

(Mercer et al., 2025)

ovariole

(Mercer et al., 2025)

ovariole (with bbn^C-HA)

(Mercer et al., 2025)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

bbn^KO has decreased cell number | oogenesis phenotype, non-enhanceable by otu^KO-M6/otu^KO-M7

(Mercer et al., 2025)

NOT suppressed by

Statement

Reference

bbn^KO has decreased cell number | oogenesis phenotype, non-suppressible by otu^KO-M6/otu^KO-M7

(Mercer et al., 2025)

bbn^KO has decreased cell number | oogenesis phenotype, non-suppressible by Sxl^cF1.otu

(Mercer et al., 2025)

bbn^KO has decreased cell number | oogenesis phenotype, non-suppressible by otu^UASp.EGFP/Scer\GAL4^nanos.PU

(Mercer et al., 2025)

NOT Enhancer of

Statement

Reference

bbn^KO is a non-enhancer of decreased cell number | oogenesis phenotype of otu^KO-M6/otu^KO-M7

(Mercer et al., 2025)

NOT Suppressor of

Statement

Reference

bbn^KO is a non-suppressor of decreased cell number | oogenesis phenotype of otu^KO-M6/otu^KO-M7

(Mercer et al., 2025)

Phenotype Manifest In

Enhanced by

Statement

Reference

bbn^KO has ovariole phenotype, enhanceable by snf¹⁴⁸

(Mercer et al., 2025)

NOT Enhanced by

Statement

Reference

bbn^KO has ovariole phenotype, non-enhanceable by otu^KO-M6/otu^KO-M7

(Mercer et al., 2025)

bbn^KO has female germline cell | decreased number phenotype, non-enhanceable by otu^KO-M6/otu^KO-M7

(Mercer et al., 2025)

NOT suppressed by

Statement

Reference

bbn^KO has female germline cell | decreased number phenotype, non-suppressible by otu^UASp.EGFP/Scer\GAL4^nanos.PU

(Mercer et al., 2025)

bbn^KO has ovariole phenotype, non-suppressible by otu^UASp.EGFP/Scer\GAL4^nanos.PU

(Mercer et al., 2025)

bbn^KO has ovariole phenotype, non-suppressible by otu^KO-M6/otu^KO-M7

(Mercer et al., 2025)

bbn^KO has female germline cell | decreased number phenotype, non-suppressible by otu^KO-M6/otu^KO-M7

(Mercer et al., 2025)

bbn^KO has ovariole phenotype, non-suppressible by Sxl^cF1.otu

(Mercer et al., 2025)

bbn^KO has female germline cell | decreased number phenotype, non-suppressible by Sxl^cF1.otu

(Mercer et al., 2025)

Enhancer of

Statement

Reference

bbn^KO is an enhancer of ovariole phenotype of snf¹⁴⁸

(Mercer et al., 2025)

NOT Enhancer of

Statement

Reference

bbn^KO is a non-enhancer of ovariole phenotype of otu^KO-M6/otu^KO-M7

(Mercer et al., 2025)

bbn^KO is a non-enhancer of female germline cell | decreased number phenotype of otu^KO-M6/otu^KO-M7

(Mercer et al., 2025)

NOT Suppressor of

Statement

Reference

bbn^KO is a non-suppressor of ovariole phenotype of otu^KO-M6/otu^KO-M7

(Mercer et al., 2025)

bbn^KO is a non-suppressor of female germline cell | decreased number phenotype of otu^KO-M6/otu^KO-M7

(Mercer et al., 2025)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

bbn^KO is rescued by Scer\GAL4^nanos.PU/bbn^UASp.cMa

(Mercer et al., 2025)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

bbn^KO

(Mercer et al., 2025)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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