FlyBase Allele Report: Dmel\tkv[unspecified]

General Information

Symbol

Dmel\tkv^unspecified

Species

D. melanogaster

Name

FlyBase ID

FBal0055978

Feature type

allele

Associated gene

Dmel\tkv

Associated Insertion(s)

Carried in Construct

Also Known As

unspecified

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

FlyBase curator comment: this entry is used to capture phenotypic information when the particular allele (or allele combination) used by the author could not be determined but the context of the experiment suggests that the phenotype being described is some kind of loss of function.

(FlyBase Curators, 2025-)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy

(McCabe et al., 2004)

lethal - all die during embryonic stage | recessive

(Tearle and Nusslein-Volhard, 1987)

some die during embryonic stage | recessive

(Tearle and Nusslein-Volhard, 1987)

Phenotype Manifest In

embryonic epidermis

(Tearle and Nusslein-Volhard, 1987)

genital disc primordium

(Chen et al., 2005)

synapse

(McCabe et al., 2004)

t-bar

(McCabe et al., 2004)

Detailed Description

Statement

Reference

Stage 15 tkv^unspecified embryos have 30-34 genital disc precursor cells, while wild type embryos have only 22 at this stage.

(Chen et al., 2005)

The number of T bars per active zone and bouton surface area per active zone is increased compared to wild type in the boutons of muscle 6/7 in mutant third instar larvae. 10 +/- 2% detachment of the presynaptic membrane is seen.

(McCabe et al., 2004)

Homozygotes do not exhibit a wing vein phenotype.

(Yu et al., 1996)

tkv^unspecified mutant embryos lack dorsal hypoderm. Internal organs appear normal and are extruded though the open dorsal side of the embryo. The ventral hypoderm is contracted.

(Tearle and Nusslein-Volhard, 1987)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressed by

Statement

Reference

tkv^unspecified has phenotype, suppressible by Egfr^t1/Egfr^f11

(Diaz-Benjumea and Garcia-Bellido, 1990)

Suppressor of

Statement

Reference

dpp^d-ho/tkv^unspecified is a suppressor of phenotype of CycE^JP

(Horsfield et al., 1998)

tkv^unspecified/tkv^unspecified is a suppressor of phenotype of Egfr^t1/Egfr^f11

(Diaz-Benjumea and Garcia-Bellido, 1990)

NOT Suppressor of

Statement

Reference

tkv^unspecified/tkv[+] is a non-suppressor of wing vein | ectopic phenotype of Egfr^E1

(Li and Li, 2003)

Other

Statement

Reference

sog^EP2, tkv^unspecified has wing vein L4 phenotype

(Yu et al., 1996)

sog^EP7, tkv^unspecified has wing vein L5 phenotype

(Yu et al., 1996)

sog^EP7, tkv^unspecified has wing vein L4 phenotype

(Yu et al., 1996)

Additional Comments

Genetic Interactions

Statement

Reference

Introduction of sog^EP2 into tkv^unspecified flies causes truncation of wing vein L4 and introduction of sog^EP7 causes severe truncation of wing veins L4 and L5.

(Yu et al., 1996)

Egfr^t1/Egfr^f11 shows a negative interaction in combination with tkv^unspecified/tkv^unspecified.

(Diaz-Benjumea and Garcia-Bellido, 1990)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

tkv^KG01923

(Dworkin and Gibson, 2006)

tkv^P906

(Tanimoto et al., 2000)

Rescued by

tkv^unspecified is rescued by tkv^hs.PR

(Ruberte et al., 1995)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

tkv^unspecified

unspecified

(Yu et al., 1996, Diaz-Benjumea and Garcia-Bellido, 1990)

Name Synonyms

Secondary FlyBase IDs

References (13)

Report Sections

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