FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\gsbprd.PX
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General Information
Symbol
Dmel\gsbprd.PX
Species
D. melanogaster
Name
paired promoter construct of Xue
FlyBase ID
FBal0057318
Feature type
allele
Associated gene
Dmel\gsb
Associated Insertion(s)
Carried in Construct
P{prd-Gsb}
Also Known As
prd-Gsb
Key Links
Transgenic product class
cDNA
(Xue and Noll, 1996)
wild_type
(Xue and Noll, 1996)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Xue and Noll, 1996)
wild_type
(Xue and Noll, 1996)
Mutagen
in vitro construct
(Xue and Noll, 1996)
Progenitor genotype
Carried in construct
P{prd-Gsb}
Cytology
Description

NotI-HindIII fragment containing the complete prd cis-regulatory region is fused to an XbaI-NheI cDNA BSH9c2 fragment of the gsb coding region, and SacII-NotI fragment of prd downstream sequences.

(Xue and Noll, 1996)
Allele components
Component
Use(s)
Regulatory region(s)
prd
Encoded product / tool
gsb
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      gsbprd.PX is a suppressor of lethal phenotype of Df(2L)Prl/prd4

      (Xue and Noll, 2002)
      NOT Suppressor of
      Statement
      Reference

      gsbprd.PX is a non-suppressor of male sterile phenotype of Df(2L)Prl/prd4

      (Xue and Noll, 2002, Xue et al., 2001)

      gsbprd.PX/gsb::Mmus\Pax3GsbN+Pax3C.prd is a non-suppressor of male sterile phenotype of Df(2L)Prl/prd4

      (Xue et al., 2001)
      Other
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      gsbprd.PX is a suppressor of embryonic/first instar larval cuticle phenotype of prd4

      (Xue et al., 2001)
      NOT Suppressor of
      Statement
      Reference

      gsbprd.PX is a non-suppressor of male accessory gland phenotype of Df(2L)Prl/prd4

      (Xue and Noll, 2002)
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The addition of prdmf5 to prd4/Df(2L)Prl animals that have been partially rescued by gsbprd.PX, fully rescues the male sterility phenotype.

      (Xue and Noll, 2002)

      One copy of gsbprd.PX partially rescues the cuticle phenotype of prd4 homozygous embryos, while two copies fully rescue the phenotype. Two copies of gsbprd.PX partially rescue viability of prd4/Df(2L)Prl adults, while one copy fails to rescue prd4/Df(2L)Prl viability. Two copies of gsbprd.PX fail to rescue the fertility of prd4/Df(2L)Prl males.

      (Xue et al., 2001)

      The addition of gsbprd.PX to prd4/Df(2L)Prl flies produces male flies that are sterile. These males exhibit normal copulatory behaviour. The testes, the ejaculatory duct, and the ejaculatory bulb are without obvious morphological defects. In addition, a normal amount of sperm is transferred to females during copulation. However, accessory glands are completely absent in these flies.

      (Xue and Noll, 2000)

      Able to rescue the cuticular phenotype of prd4/Df(2L)Prl transheterozygous embryos and rescue them to viable adults. Adults exhibit distorted abdominal phenotype due to disorganisation of segments. One copy of each P{prd-Gsb} and P{prd-Pax3} give most efficient rescue of prd transheterozygous embryos, viable adults also show distorted abdominal phenotype.

      (Xue and Noll, 1996)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      gsb-dprd.PX
      gsbprd.PX
      Name Synonyms
      paired promoter construct of Xue
      (Xue and Noll, 1996)
      Secondary FlyBase IDs
        References (5)