FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\exdUAS.cGa
Open Close
General Information
Symbol
Dmel\exdUAS.cGa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Gonzalez-Crespo
FlyBase ID
FBal0057453
Feature type
allele
Associated gene
Dmel\exd
Associated Insertion(s)
Carried in Construct
P{UAS-exd.G}
Also Known As
UAS-exd
Key Links
Transgenic product class
cDNA
(Gonzalez-Crespo and Morata, 1996)
wild_type
(Gonzalez-Crespo and Morata, 1996)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Gonzalez-Crespo and Morata, 1996)
wild_type
(Gonzalez-Crespo and Morata, 1996)
Mutagen
in vitro construct
(Casares et al., 1996, Gonzalez-Crespo and Morata, 1996)
Progenitor genotype
Carried in construct
P{UAS-exd.G}
Cytology
Description

UASt regulatory sequences drive expression of a full-length exd cDNA.

(Gonzalez-Crespo and Morata, 1996)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
exd
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Scer\GAL4444- or Scer\GAL4ptc-559.1-mediated expression does not cause a morphological alteration in the cuticle of first instar larvae.

      (Azpiazu and Morata, 1998)

      Expression of hthScer\UAS.cPa under the control of Scer\GAL4dpp.blk1 has no effect on eye development.

      (Pai et al., 1998)

      Scer\GAL4Bx-MS1096 or Scer\GAL4C-765 induced expression of P{UAS-Ubx.Ia.M} or P{UAS-abd-A.M} in the wing disc causes transformation of the wing into haltere-like tissue. Co-expression of P{UAS-exd.G} (induced by Scer\GAL4Bx-MS1096) does not significantly modify the wing transformation.

      (Casares et al., 1996)

      Scer\GAL4E132 mediated expression in the central region of the leg disc causes deformations in the central folds, the basitarsus is fused to the proximal femur due to disappearance of the distal femur and tibia. Scer\GAL4Dll-md23 mediated expression all over the leg disc causes a complete disappearance of the central wings and a severe reduction in the size of the leg disc. Adult legs appear truncated, only containing coxa, trochanter and proximal femur. Scer\GAL4dpp.blk1 mediated expression in the leg disc causes reduction of all distal structures (coxa, trochanter and proximal femur are unaffected).

      (Gonzalez-Crespo and Morata, 1996)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Suppressor of
      Statement
      Reference

      exdUAS.cGa/Scer\GAL4Bx-MS1096 is a non-suppressor of visible phenotype of Scer\GAL4Bx-MS1096, abd-A1dB5.UAS

      (Casares et al., 1996)
      Phenotype Manifest In
      NOT Enhancer of
      Statement
      Reference

      exdUAS.cGa/Scer\GAL4ey.PH is a non-enhancer of eye disc | somatic clone phenotype of L2

      (Singh et al., 2011)

      exdUAS.cGa/Scer\GAL4ey.PH is a non-enhancer of eye | somatic clone phenotype of L2

      (Singh et al., 2011)
      Suppressor of
      NOT Suppressor of
      Statement
      Reference

      exdUAS.cGa/Scer\GAL4ey.PH is a non-suppressor of eye disc | somatic clone phenotype of L2

      (Singh et al., 2011)

      exdUAS.cGa/Scer\GAL4ey.PH is a non-suppressor of eye | somatic clone phenotype of L2

      (Singh et al., 2011)

      exdUAS.cGa/Scer\GAL4Bx-MS1096 is a non-suppressor of wing phenotype of Scer\GAL4Bx-MS1096, abd-A1dB5.UAS

      (Casares et al., 1996)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Overexpression of exdScer\UAS.cGa under the control of Scer\GAL4ey.PH in a L2 heterozygous background does not affect the loss-of-ventral-eye phenotype found in L2/+ mutants.

      (Singh et al., 2011)

      Co-expression of exdScer\UAS.cGa in combination with AntpScer\UAS.cBa or AntpAAAA.Scer\UAS in the presence of Nact.sev all under the control of Scer\GAL4ey.PH results in approximately 2% of flies exhibiting wing structures in the eye region, compared to around 40% when exdScer\UAS.cGa is absent. Only 3% of these flies show antenna-to-leg transformation compared with 28% without exdScer\UAS.cGa. The presence of exdScer\UAS.cGa also inhibits antenna-to-leg transformation induced by AntpAAAA.Scer\UAS from 19% to 4.5% (in a Nact.sev and Scer\GAL4ey.PH background).

      (Prince et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      exdScer\UAS.cGa
      exdUAS.cGa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Gonzalez-Crespo
      (Casares et al., 1996, Gonzalez-Crespo and Morata, 1996)
      Secondary FlyBase IDs
        References (10)