FlyBase Allele Report: Dmel\egh[9pp4]

General Information

Symbol

Dmel\egh^9pp4

Species

D. melanogaster

Name

FlyBase ID

FBal0057543

Feature type

allele

Associated gene

Dmel\egh

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Goode et al., 1996)

Progenitor genotype

Cytology

Description

15bp deletion removing the sequence encoding amino acids 113-117.

(Wandall et al., 2005)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

X:2,596,551..2,596,565 [+]

Comment:

A 15bp deletion of the sequence encoding amino acids 113-117.

(Wandall et al., 2005)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy

(Fan et al., 2005)

female sterile

(Goode et al., 1996)

increased occurrence of cell division | germline clone

(Goode et al., 1996)

lethal

(Wandall et al., 2005)

lethal | recessive

(Williams et al., 1995)

lethal - all die before end of pupal stage | recessive

(Goode et al., 1996)

some die during pupal stage | recessive

(Goode et al., 1996)

Phenotype Manifest In

dorsal appendage | germline clone

(Goode et al., 1996)

egg chamber | germline clone

(Goode et al., 1996)

female germline cyst | germline clone

(Goode et al., 1996)

follicle cell | germline clone

(Goode et al., 1996)

lamina plexus

(Fan et al., 2005)

nurse cell | germline clone

(Goode et al., 1996)

oocyte | germline clone

(Goode et al., 1996)

photoreceptor cell R1 & axon

(Fan et al., 2005)

photoreceptor cell R2 & axon

(Fan et al., 2005)

photoreceptor cell R3 & axon

(Fan et al., 2005)

photoreceptor cell R4 & axon

(Fan et al., 2005)

photoreceptor cell R5 & axon

(Fan et al., 2005)

photoreceptor cell R6 & axon

(Fan et al., 2005)

presumptive embryonic/larval nervous system | germline clone

(Goode et al., 1996)

stalk follicle cell | germline clone

(Goode et al., 1996)

Detailed Description

Statement

Reference

In egh^9pp4 third instar visual systems, R-cell axonal projections are defective and the lamina plexus is discontinuous and of variable thickness.

(Fan et al., 2005)

Females with germline clones lay eggs with fused dorsal appendages and the embryos have an expanded nervous system. Only a few eggs are laid because early oogenesis is blocked due to the development of egg chambers containing multiple oocyte-nurse cell complexes. Germ cell divisions in the egg chambers are not regulated. Follicle cells display an unusual behaviour; organised as an epithelial sheet within the germarium that encapsulates germ cells. Follicle cells also migrate between germ cells, not around them, perhaps splitting them in two. Follicle cells at the posterior of egg chamber become mesenchymal-like indicating they have not adopted a border cell fate. Stalk cells are determined correctly but are usually disorganised compared to wild type.

(Goode et al., 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

egh^9pp4 has abnormal neuroanatomy phenotype, non-enhanceable by brn^l.6P6

(Fan et al., 2005)

Suppressed by

Statement

Reference

egh^9pp4 has abnormal neuroanatomy phenotype, suppressible by Hsap\B4GALT6^UAS.cWa/Scer\GAL4^arm.PS

(Fan et al., 2005)

egh^9pp4 has lethal phenotype, suppressible by Hsap\B4GALT6^UAS.cWa/Scer\GAL4^arm.PS

(Wandall et al., 2005)

egh^9pp4 has lethal phenotype, suppressible by Hsap\B4GALT6^UAS.cWa/Scer\GAL4^Tub.PU

(Wandall et al., 2005)

NOT suppressed by

Statement

Reference

brn^l.6P6, egh^9pp4 has abnormal neuroanatomy phenotype, non-suppressible by Hsap\B4GALT6^UAS.cWa/Scer\GAL4^arm.PS

(Fan et al., 2005)

Other

Statement

Reference

Hsap\B4GALT6^UAS.cWa, Scer\GAL4^arm.PS, egh^9pp4 has female fertile phenotype

(Wandall et al., 2005)

Hsap\B4GALT6^UAS.cWa, Scer\GAL4^arm.PS, egh^9pp4 has male fertile phenotype

(Wandall et al., 2005)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

egh^9pp4 has photoreceptor cell R4 & axon phenotype, non-enhanceable by brn^l.6P6

(Fan et al., 2005)

egh^9pp4 has photoreceptor cell R5 & axon phenotype, non-enhanceable by brn^l.6P6

(Fan et al., 2005)

egh^9pp4 has photoreceptor cell R6 & axon phenotype, non-enhanceable by brn^l.6P6

(Fan et al., 2005)

egh^9pp4 has photoreceptor cell R1 & axon phenotype, non-enhanceable by brn^l.6P6

(Fan et al., 2005)

egh^9pp4 has photoreceptor cell R2 & axon phenotype, non-enhanceable by brn^l.6P6

(Fan et al., 2005)

egh^9pp4 has photoreceptor cell R3 & axon phenotype, non-enhanceable by brn^l.6P6

(Fan et al., 2005)

Suppressed by

Statement

Reference

egh^9pp4 has photoreceptor cell R4 & axon phenotype, suppressible by Hsap\B4GALT6^UAS.cWa/Scer\GAL4^arm.PS

(Fan et al., 2005)

egh^9pp4 has photoreceptor cell R5 & axon phenotype, suppressible by Hsap\B4GALT6^UAS.cWa/Scer\GAL4^arm.PS

(Fan et al., 2005)

egh^9pp4 has photoreceptor cell R6 & axon phenotype, suppressible by Hsap\B4GALT6^UAS.cWa/Scer\GAL4^arm.PS

(Fan et al., 2005)

egh^9pp4 has photoreceptor cell R1 & axon phenotype, suppressible by Hsap\B4GALT6^UAS.cWa/Scer\GAL4^arm.PS

(Fan et al., 2005)

egh^9pp4 has photoreceptor cell R2 & axon phenotype, suppressible by Hsap\B4GALT6^UAS.cWa/Scer\GAL4^arm.PS

(Fan et al., 2005)

egh^9pp4 has photoreceptor cell R3 & axon phenotype, suppressible by Hsap\B4GALT6^UAS.cWa/Scer\GAL4^arm.PS

(Fan et al., 2005)

NOT suppressed by

Statement

Reference

brn^l.6P6, egh^9pp4 has photoreceptor cell R1 & axon phenotype, non-suppressible by Hsap\B4GALT6^UAS.cWa/Scer\GAL4^arm.PS

(Fan et al., 2005)

brn^l.6P6, egh^9pp4 has photoreceptor cell R2 & axon phenotype, non-suppressible by Hsap\B4GALT6^UAS.cWa/Scer\GAL4^arm.PS

(Fan et al., 2005)

brn^l.6P6, egh^9pp4 has photoreceptor cell R3 & axon phenotype, non-suppressible by Hsap\B4GALT6^UAS.cWa/Scer\GAL4^arm.PS

(Fan et al., 2005)

brn^l.6P6, egh^9pp4 has photoreceptor cell R4 & axon phenotype, non-suppressible by Hsap\B4GALT6^UAS.cWa/Scer\GAL4^arm.PS

(Fan et al., 2005)

brn^l.6P6, egh^9pp4 has photoreceptor cell R5 & axon phenotype, non-suppressible by Hsap\B4GALT6^UAS.cWa/Scer\GAL4^arm.PS

(Fan et al., 2005)

brn^l.6P6, egh^9pp4 has photoreceptor cell R6 & axon phenotype, non-suppressible by Hsap\B4GALT6^UAS.cWa/Scer\GAL4^arm.PS

(Fan et al., 2005)

NOT Enhancer of

Statement

Reference

egh^9pp4 is a non-enhancer of photoreceptor cell R2 & axon phenotype of brn^l.6P6

(Fan et al., 2005)

egh^9pp4 is a non-enhancer of photoreceptor cell R3 & axon phenotype of brn^l.6P6

(Fan et al., 2005)

egh^9pp4 is a non-enhancer of photoreceptor cell R4 & axon phenotype of brn^l.6P6

(Fan et al., 2005)

egh^9pp4 is a non-enhancer of photoreceptor cell R5 & axon phenotype of brn^l.6P6

(Fan et al., 2005)

egh^9pp4 is a non-enhancer of photoreceptor cell R6 & axon phenotype of brn^l.6P6

(Fan et al., 2005)

egh^9pp4 is a non-enhancer of photoreceptor cell R1 & axon phenotype of brn^l.6P6

(Fan et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

The R-cell axonal projection phenotype of brn^l.6P6 and egh^9pp4 mutants is not enhanced when flies carry both mutations simultaneously.

(Fan et al., 2005)

Xenogenetic Interactions

Statement

Reference

Expression of Hsap\β4Gal-T6^Scer\UAS.cWa, under the control of Scer\GAL4^arm.PS, in egh^9pp4 mutants rescues the R-cell axonal projection phenotype. However, Scer\GAL4^arm.PS > Hsap\β4Gal-T6^Scer\UAS.cWa expression does not rescue the R-cell axonal projection phenotype in brn^l.6P6 egh^9pp4 double mutants.