FlyBase Allele Report: Dmel\nmo[adk1]

General Information

Symbol

Dmel\nmo^adk1

Species

D. melanogaster

Name

FlyBase ID

FBal0057941

Feature type

allele

Associated gene

Dmel\nmo

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Verheyen et al., 1996)

Progenitor genotype

Cytology

Description

Mutation resulting in alterations in the pattern of transcripts produced (truncated transcripts are produced in pupae).

(Verheyen et al., 2001)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Kennedy's disease

modeled by Hsap\AR^61Q.UAS

(Todd et al., 2015)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

adult head bristle

(Verheyen et al., 2001)

crossvein | ectopic

(Verheyen et al., 1996)

denticle | germline clone | maternal effect

(Mirkovic et al., 2002)

embryonic/first instar larval cuticle | germline clone | maternal effect

(Mirkovic et al., 2002)

embryonic head | germline clone | maternal effect

(Mirkovic et al., 2002)

embryonic segment | germline clone | maternal effect

(Mirkovic et al., 2002)

eye

(Mirkovic et al., 2002, Verheyen et al., 1996)

mesothoracic tergum & macrochaeta

(Verheyen et al., 2001)

ommatidium

(Mirkovic et al., 2002, Verheyen et al., 1996)

secondary pigment cell | ectopic

(Mirkovic et al., 2002)

tertiary pigment cell | ectopic

(Mirkovic et al., 2002)

ventral denticle belt | germline clone | maternal effect

(Mirkovic et al., 2002)

wing

(Verheyen et al., 2001, Verheyen et al., 1996)

wing vein | ectopic

(Zeng et al., 2007, Verheyen et al., 2001)

Detailed Description

Statement

Reference

Mutant flies have a mild ectopic vein phenotype in the wing.

(Zeng et al., 2007)

nmo^adk1 germline clones result in embryonic lethality characterized by moderate head defects in 80% of clonal embryos. The embryos also display moderate and variable segmentation defects, including loss of denticle structures. They also show a reduction in embryonic cell death, particularly in the head region. Post death stage homozygous nmo^adk1 pupal retinae have an increased density of secondary/tertiary pigment cells compared to wild-type. Unlike wild-type, the local density of these cells is variable: dependent on the specific aberrations in ommatidial shape and orientation in the region in question. In some regions the ommatidia are square-like and have approximately wild-type numbers of secondary/tertiary cells. In other regions of the same retina, ommatidia retain a hexagonal- like shape but have increased numbers of secondary/tertiary pigment cells.

(Mirkovic et al., 2002)

Mutant flies have a shorter, broader wing than normal. Excess wing vein tissue originating from the posterior crossvein and extending distally between veins L4 and L5 is seen (this phenotype is fully penetrant). Additional vein material can also form parallel to vein L2 and posterior to vein L5. The wings are held away from the body at a 45^o angle. Flies show a variable polarity defect in the wing. Homozygotes show a mild loss of bristles on the head and notum (having an average of 37.4 +/- 1.71 bristles compared to the wild-type number of 40) and occasionally have bent or duplicated bristles.

(Verheyen et al., 2001)

Semi-lethal, rare homozygous flies display rough, small eyes and several wing phenotypes. Wings are rounder and shorter and held out at an angle from the body, and also display ectopic cross vein material.

(Verheyen et al., 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

nmo^adk1 has visible phenotype, enhanceable by Dad^j1E4

(Zeng et al., 2007)

Suppressed by

Statement

Reference

nmo^adk2/nmo^adk1 has visible phenotype, suppressible by Scer\GAL4^32B/E(spl)mβ-HLH^UAS.cdCa

(Verheyen et al., 2001)

Enhancer of

Statement

Reference

nmo^adk2/nmo^adk1 is an enhancer of visible | dominant phenotype of H¹

(Verheyen et al., 2001)

nmo^adk1/nmo^adk1 is an enhancer of visible | dominant phenotype of H¹

(Verheyen et al., 2001)

Phenotype Manifest In

Enhanced by

Statement

Reference

nmo^adk1 has wing vein | ectopic phenotype, enhanceable by Dad^j1E4

(Zeng et al., 2007)

Suppressed by

Statement

Reference

nmo^adk2/nmo^adk1 has wing vein | ectopic phenotype, suppressible by Scer\GAL4^32B/E(spl)mβ-HLH^UAS.cdCa

(Verheyen et al., 2001)

Enhancer of

Statement

Reference

nmo^adk2/nmo^adk1 is an enhancer of adult head bristle phenotype of H¹

(Verheyen et al., 2001)

nmo^adk2/nmo^adk1 is an enhancer of mesothoracic tergum & macrochaeta phenotype of H¹

(Verheyen et al., 2001)

nmo^adk1/nmo^adk1 is an enhancer of adult head bristle phenotype of H¹

(Verheyen et al., 2001)

nmo^adk1/nmo^adk1 is an enhancer of mesothoracic tergum & macrochaeta phenotype of H¹

(Verheyen et al., 2001)

nmo^adk1 is an enhancer of phenotype of N^nucl.sev

(Verheyen et al., 1996)

Additional Comments

Genetic Interactions

Statement

Reference

The severity of the ectopic wing vein phenotype seen in nmo^adk1 flies is increased in Dad^j1E4 ; nmo^adk1 double mutants.

(Zeng et al., 2007)

Heterozygosity for nmo^adk1 partially rescues the small eye size of rpr^GMR.PH animals.

(Mirkovic et al., 2002)

The loss of bristles on the head and notum seen in H¹/+ flies is dramatically enhanced by nmo^adk1/nmo^adk1 or nmo^adk1/nmo^adk2. Expression of HLHmβ^{Scer\UAS.cdCa} under the control of Scer\GAL4^32B completely suppresses the extra wing vein phenotype of nmo^adk1/nmo^adk2 flies.

(Verheyen et al., 2001)

Second site dominant enhancer of N^nucl.sev that increases the roughness of the eye, eye shape is smaller and flatter and eyes appear more glossy or shiny.

(Verheyen et al., 1996)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

nmo^adk2/nmo^adk1 is rescued by nmo^c5-1.UAS/Scer\GAL4^bs-1348

(Verheyen et al., 2001)

Comments

Expression of nmo^{c5-1.Scer\UAS} under the control of Scer\GAL4^bs-1348 rescues the extra wing vein phenotype seen in nmo^adk1/nmo^adk2 flies.

(Verheyen et al., 2001)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

adk^eN9

nmo^adk1

(Todd et al., 2015, Braid et al., 2010, Fiehler and Wolff, 2008, Zeng et al., 2007)

nmo^eN9

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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