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General Information
Symbol
Dmel\Scrunspecified
Species
D. melanogaster
Name
FlyBase ID
FBal0058273
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Mutagen
    Nature of the Allele
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    Homozygous clones in the labium result in a reduction of pseudotracheal rows.

    Ectopic expression of Scr results in transformation of arista to tarsus.

    No gross abnormalities in brain patterning are seen in homozygous embryos. Longitudinal pathways and commissural pathways are present and appear normal. The maxillary organs of the peripheral nervous system are duplicated.

    Homozygous embryos show homeotic transformation of segments T1 to T2 and labium to maxilla. Heterozygous males have fewer sex combs than wild-type flies.

    Homozygous embryos show a partial transformation of prothorax to mesothorax. The labium is absent, and a second pair of maxillary sense organs lies between the normal mouthparts and prothorax. The mesothorax, metathorax and abdominal segments appear normal. Homozygous escunspecified embryos (derived from homozygous escunspecified mothers) that lack Scr+ are identical to homozygous escunspecified embryos (derived from homozygous escunspecified mothers) except that the labial pits are absent and are replaced by a second pair of maxillary sense organs, and the small tuft of ventral hairs associated with the labial pits are enlarged to form a square band of three to five rows of hairs. Antpunspecified Scrunspecified embryos have bilaterally symmetric regions of sclerotised cuticle in the prothorax.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Phenotype Manifest In
    Additional Comments
    Genetic Interactions
    Statement
    Reference

    pbunspecified Scrunspecified double mutant clones in the labium result in a transformation of labium to antenna (the transformed structure contains the a3 segment and terminal arista).

    pbunspecified Scrunspecified ssunspecified triple mutant clones and pbunspecified Scrunspecified hth5E04 ssunspecified mutant clones in the labium result in a 100% penetrant transformation of labium to stunted legs. These legs have claws and appear to be composed of three segments, but show no sign of tarsal articulation.

    Scrunspecified, Antpunspecified, Ubxunspecified, abd-Aunspecified, Abd-Bunspecified mutants are profoundly affected in their development with abnormal or twisted dorsal closure.

    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (2)
    Reported As
    Symbol Synonym
    Scrunspecified
    unspecified
    Name Synonyms
    Secondary FlyBase IDs
      References (9)