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General Information
Symbol
Dmel\nejΔQ.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0175575
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-CBP ΔQ
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of a truncated form of nej (encodes amino acids 1-2677).

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of nejΔQ.Scer\UAS under the control of Scer\GAL4GMR.PU does not result in any obvious eye phenotypes in adults.

Scer\GAL4GMR.PF-driven expression of nejΔQ.Scer\UAS results in 100% lethality at the early pupal stage.

Expression of nejΔQ.Scer\UAS under the control of Scer\GAL4hs.2sev results in loss of ommatidia within the middle of the retina. The remaining ommatidia lack variable numbers of photoreceptors.

Animals expressing nejΔQ.Scer\UAS under the control of Scer\GAL4GMR.PF die shortly after cessation of larval development. Each ommatidium in the larval eye disc contains only the R8, R2 and R5 photoreceptors, suggesting that ommatidial assembly is blocked at the recruitment of the photoreceptor R3/R4 pair. Expression of nejΔQ.Scer\UAS under the control of Scer\GAL4hs.2sev results in almost complete deletion of the eye. Expression of nejΔQ.Scer\UAS under the control of Scer\GAL4ey.PH blocks initiation pattern formation in the eye disc, which results in complete elimination of the eye in the adult. The severe rough eye phenotype caused by expression of nejΔQ.Scer\UAS under the control of Scer\GAL4hs.2sev is not affected if the flies also carry nej3/+.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Enhanced by
NOT suppressed by
Suppressor of
NOT Suppressor of
Statement
Reference

nejΔQ.UAS/Scer\GAL4unspecified is a non-suppressor of visible | dominant phenotype of soD

Phenotype Manifest In
Enhanced by
Suppressed by
NOT suppressed by
Statement
Reference

Scer\GAL4hs.2sev, nejΔQ.UAS has eye phenotype, non-suppressible by Df(3L)H99

Suppressor of
NOT Suppressor of
Statement
Reference

nejΔQ.UAS/Scer\GAL4unspecified is a non-suppressor of eye phenotype of soD

Additional Comments
Genetic Interactions
Statement
Reference

Expression of nejΔQ.Scer\UAS under the control of Scer\GAL4unspecified does not suppress the no-eye phenotype of soD/+.

Xenogenetic Interactions
Statement
Reference

Co-expression of nejΔQ.Scer\UAS partially rescues the small eye and lens fusion phenotype seen in adult flies expressing Hsap\APPAβ42.Scer\UAS.cUa under the control of Scer\GAL4GMR.PU. Co-expression of nejΔQ.Scer\UAS partially suppresses the increased cell death observed in third instar eye discs of flies expressing Hsap\APPAβ42.Scer\UAS.cUa under the control of Scer\GAL4GMR.PU.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
nejΔQ.Scer\UAS
nejΔQ.UAS
Name Synonyms
Secondary FlyBase IDs
    References (5)