FlyBase Allele Report: Dmel\ctp[exc6]

General Information

Symbol

Dmel\ctp^exc6

Species

D. melanogaster

Name

FlyBase ID

FBal0059194

Feature type

allele

Associated gene

Dmel\ctp

Associated Insertion(s)

Carried in Construct

Also Known As

ddlc1^exc6

Key Links

Allele class

amorphic allele - genetic evidence

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Ghosh-Roy et al., 2004, Dick et al., 1996)

Mutagen

Delta2-3 transposase

(Dick et al., 1996)

Progenitor genotype

ctp^ins1

(Dick et al., 1996)

Cytology

Description

Imprecise excision of the P{lacW} element and deletion of entire 2.4kb transcription unit.

(Dick et al., 1996)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal (with Df(1)bi-DL1)

(Ghosh-Roy et al., 2004)

lethal | recessive

(Ghosh-Roy et al., 2004)

lethal - all die during embryonic stage | partially | recessive

(Dick et al., 1996)

some die during embryonic stage | recessive

(Dick et al., 1996)

visible (with ctp^DIA5)

(Ghosh-Roy et al., 2004)

visible (with ctp^DIIA82)

(Ghosh-Roy et al., 2004)

visible (with ctp^DIIB14)

(Ghosh-Roy et al., 2004)

visible (with ctp^exc39)

(Ghosh-Roy et al., 2004)

visible (with ctp^exc41)

(Ghosh-Roy et al., 2004)

visible (with ctp^exc123)

(Ghosh-Roy et al., 2004)

visible (with ctp^ins1)

(Ghosh-Roy et al., 2004)

Phenotype Manifest In

astral microtubule

(Wang et al., 2011)

astral microtubule (with Df(1)JC70)

(Wang et al., 2011)

egg chamber

(Dick et al., 1996)

larval neuroblast

(Wang et al., 2011)

larval neuroblast (with Df(1)JC70)

(Wang et al., 2011)

macrochaeta (with ctp^DIA5)

(Ghosh-Roy et al., 2004)

macrochaeta (with ctp^DIIA82)

(Ghosh-Roy et al., 2004)

macrochaeta (with ctp^DIIB14)

(Ghosh-Roy et al., 2004)

macrochaeta (with ctp^exc39)

(Ghosh-Roy et al., 2004)

macrochaeta (with ctp^exc41)

(Ghosh-Roy et al., 2004)

macrochaeta (with ctp^exc123)

(Ghosh-Roy et al., 2004)

macrochaeta (with ctp^ins1)

(Ghosh-Roy et al., 2004)

ovariole

(Dick et al., 1996)

wing (with ctp^DIA5)

(Ghosh-Roy et al., 2004)

wing (with ctp^DIIA82)

(Ghosh-Roy et al., 2004)

wing (with ctp^DIIB14)

(Ghosh-Roy et al., 2004)

wing (with ctp^exc39)

(Ghosh-Roy et al., 2004)

wing (with ctp^exc41)

(Ghosh-Roy et al., 2004)

wing (with ctp^exc123)

(Ghosh-Roy et al., 2004)

wing (with ctp^ins1)

(Ghosh-Roy et al., 2004)

Detailed Description

Statement

Reference

Homozygous and ctp^exc6/Df(1)JC70 neuroblasts show defects in mitotic spindle orientation. Among the homozygous neuroblasts with misoriented spindles, 62% lack astral microtubules.

(Wang et al., 2011)

The following transheterozygotes exhibit thin bristles and erect wings: ctp^exc6/ctp^exc39, ctp^exc6/ctp^exc123, ctp^exc6/ctp^DIIB14, ctp^exc6/ctp^exc41, ctp^exc6/ctp^DIA5, ctp^exc6/ctp^ins1 and ctp^exc6/ctp^DIIA82.

(Ghosh-Roy et al., 2004)

Homozygous embryos do not develop past stage 10. Degenerating embryos exhibit disorganised cellular morphology (degradation of genomic DNA) and cytoplasmic condensation and fragmentation, indication of programmed cell death. Homozygous ctp^ins1 females exhibit disorganisation of ovarioles and egg chambers, disorganisation is more severe when transheterozygous with ctp^exc6.

(Dick et al., 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

ctp^exc6 has lethal phenotype, suppressible by Scer\GAL4^da.G32/Hsap\DYNLL1^UAS.Tag:MYC

(Ghosh-Roy et al., 2004)

Phenotype Manifest In

Suppressed by

Statement

Reference

ctp^exc6 has macrochaeta phenotype, suppressible by Scer\GAL4^da.G32/Hsap\DYNLL1^UAS.Tag:MYC

(Ghosh-Roy et al., 2004)

ctp^exc6 has wing phenotype, suppressible by Scer\GAL4^da.G32/Hsap\DYNLL1^UAS.Tag:MYC

(Ghosh-Roy et al., 2004)

Additional Comments

Genetic Interactions

Statement

Reference

ctp^exc6 mud¹ double mutant neuroblasts have more severe mitotic spindle orientation defects than either single mutant.

(Wang et al., 2011)

Xenogenetic Interactions

Statement

Reference

Expression of Hsap\DNCL1^{Scer\UAS.T:Hsap\MYC}, driven by Scer\GAL4^da.G32, rescues the lethality and the thin bristle and erect wing phenotypes of ctp^exc6 hemizygous mutants.

(Ghosh-Roy et al., 2004)

Complementation and Rescue Data

Rescued by

ctp^exc6 is rescued by Scer\GAL4^insc-Mz1407/ctp^UAS.Venus

(Wang et al., 2011)

ctp^exc6 is rescued by ctp^UASp.cGa/Scer\GAL4^da.G32

(Ghosh-Roy et al., 2004)

Not rescued by

ctp^exc6 is not rescued by Scer\GAL4^insc-Mz1407/ctp^{UAS.Venus,Tag:CAAX(Unk)}

(Wang et al., 2011)

Comments

Expression of ctp^{Scer\UAS.T:Avic\GFP-YFP.Venus} under the control of Scer\GAL4^insc-Mz1407 rescues the spindle misorientation phenotype seen in ctp^exc6 neuroblasts.

Expression of ctp^{Scer\UAS.T:Avic\GFP-YFP.Venus,T:Uuuu\CAAX} under the control of Scer\GAL4^insc-Mz1407 fails to rescue the spindle misorientation phenotype seen in ctp^exc6 neuroblasts.

(Wang et al., 2011)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Cdlc1^exc6

ctp^exc6

(Chen et al., 2016, Wang et al., 2011)

ddlc1^exc6

(Ghosh-Roy et al., 2004, Dick et al., 1996)

Name Synonyms

Secondary FlyBase IDs

References (4)

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