Open Close
General Information
Symbol
Dmel\tupUAS.cTa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Thor
FlyBase ID
FBal0060384
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-tup, UAS-isl
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

A truncated tup cDNA (nucleotides 425 to 2982) is expressed under the control of UAS regulatory sequences.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of tupScer\UAS.cTa under the control of Scer\GAL4twi.2PE does not induce alary muscle duplications in embryos.

Expression of tupScer\UAS.cTa in body wall muscle (under the control of Scer\GAL4how-24B) reduces the magnitude of K[+] fast currents.

Embryos expressing tupScer\UAS.cTa under the control of Scer\GAL4twi.PB show a transformation of muscle DA3 to DA2 in 88% of segments.

Mis-expression of tupScer\UAS.cTa under the control of Scer\GAL4ey.PH reduces or abolishes the eye.

Expression of tupScer\UAS.cTa under the control of Scer\GAL4C-765 results in the formation of notum-like tissue in the mesothoracic pleura and extra notum-like bristles on the tegula.

Expression of tupScer\UAS.cTa, under the control of Scer\GAL4pnr-MD237, affects the development of the dorsocentral and scutellar bristles and induces a thoracic cleft.

Expression of tupScer\UAS.cTa, under the control of Scer\GAL4ap-md544, results in the formation of rudimentary wings.

The legs of tupScer\UAS.cTa; Scer\GAL4ap-md544 flies lack a fourth tarsal segment. tupScer\UAS.cTa; Scer\GAL4dpp.blk1 flies the femur, tibia and first tarsal segment are fused. In the pretarsus only one claw develops.

tupisl-1 mutants expressing tupScer\UAS.cTa using Scer\GAL4elav.PLu do not hatch. Produces changes in axonal projections of interneurons and motor neurons, when expressed using Scer\GAL4sca-537.4. Motor neurons that normally innervate dorsal muscles often remain within the ventral muscle region. Both ISN and SNa motor axons often fail to reach their normal target areas and show abnormal arborisations over the ventral muscle region.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Co-expression of Lim3Scer\UAS.cTa enhances the reduction in K[+] fast currents found upon expression of tupScer\UAS.cTa under the control of Scer\GAL4how-24B.

Expression of tupScer\UAS.cTa with BxEP1306, both under the control of Scer\GAL4Ccap.PP, suppresses the wing expansion defect found upon expression of BxEP1306 alone.

Co-expression of both tupScer\UAS.cTa and araScer\UAS.cGa under the control of Scer\GAL4C-765 results in the wing and wing hinge being replaced by a large structure of notum-like tissue.

Co-expression of both tupScer\UAS.cTa and araScer\UAS.cGa under the control of Scer\GAL4dpp.blk1 transforms the central part of the wing to notum-like tissue, whereas the anterior and posterior parts develop as wing tissue. The animals also show notum-like structures near the coxa, indicating transformation of the ventral region of the body wall towards notum.

Coexpression of the apScer\UAS.cOa transgene rescues the rudimentary wing phenotype of Scer\GAL4ap-md544>tupScer\UAS.cTa flies.

Expression of tupScer\UAS.cTa, under the control of Scer\GAL4ap-md544, in a ChiE background causes no wing defects.

Expression of tupScer\UAS.cTa, under the control of Scer\GAL4pnr-MD237, partially suppresses the excess scutellar bristle phenotype of ChiE mutants.

The loss of tarsal segment 4 in the legs of tupScer\UAS.cTa; Scer\GAL4ap-md544 flies is not suppressed by apScer\UAS.cOa or ChiFL.Scer\UAS.T:Hsap\MYC, but is partially suppressed by BScer\UAS.cKa.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (3)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Symbol Synonym
islUAS.cTa
tupScer\UAS.cTa
tupUAS.cTa
Name Synonyms
Saccharomyces cerevisiae UAS construct a of Thor
Secondary FlyBase IDs
    References (12)