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General Information
Symbol
Dsim\Lhrunspecified
Species
D. simulans
Name
FlyBase ID
FBal0060719
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
unspecified
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
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    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    Dsim\Lhrunspecified can rescue the sterility of hybrid female progeny of D.melanogaster females crossed to D.simulans males.

    Hybrid daughters from a cross of D.melanogaster females to D.simulans males are poorly viable at high temperatures (29o). This female lethality is suppressed by D.simulans Dsim\Lhrunspecified. Hybrid males from a cross of D.melanogaster females to D.simulans males are not viable. This male lethality is fully rescued at 18oC and 25oC and poorly rescued at 29oC by D.simulans Dsim\Lhrunspecified. The rescuing activity of D.simulans Dsim\Lhrunspecified is strongly suppressed by D.melanogaster Dp(1;2)v+75d. D.melanogaster Dp(1;2)v+75d has no significant effect on hybrid female viability in crosses of D.melanogaster females to D.simulans Dsim\Lhrunspecified males, suggesting that D.simulans Dsim\Lhrunspecified suppresses the deleterious effect of Dp(1;2)v+75d normally seen in female hybrids.

    Dsim\Lhrunspecified rescues the viability of hybrid males derived from a cross between D.simulans males and D.melanogaster females.

    Dsim\Lhrunspecified rescues D.melanogaster/D.simulans hybrid males (derived from a cross of D.melanogaster females to D.simulans males) that would normally be inviable. Dsim\Lhrunspecified allows the recovery of significantly more D.melanogaster/D.simulans hybrid males carrying Dp(1;2)v+75d and derived from a cross of D.melanogaster attached-X females to D.simulans males than in controls.

    The sex ratios of progeny from a cross of D.simulans Dsim\Lhrunspecified males to D.melanogaster prod+ or produnspecified/+ females are not significantly different from 0.5 or from each other.

    Dsim\Lhrunspecified rescues hybrid males from a cross between D.melanogaster mit1 females and Dsim\Lhrunspecified males. X/O clones are recovered on the head and thorax of the hybrid flies and are larger than the clones produced in a cross between D.melanogaster mit1 females and Dsim\Lhr+ males.

    Dsim\Lhrunspecified does not suppress the lethality of recombinant hybrid clones in D.melanogaster/D.simulans hybrid females.

    External Data
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    Phenotypic Class
    Suppressed by
    NOT suppressed by
    Statement
    Reference

    Dsim\Lhrunspecified has viable phenotype, non-suppressible | male limited by Nup160EP372/Nup160[+]

    Dsim\Lhrunspecified has viable phenotype, non-suppressible | male limited by l(2)SH2055[+]/Nup160SH2055

    Other
    Statement
    Reference
    Phenotype Manifest In
    Additional Comments
    Genetic Interactions
    Statement
    Reference
    Xenogenetic Interactions
    Statement
    Reference

    Nup160EP372M180/Dsim\Lhrunspecified mutant males are lethal.

    Df(2L)EP372M190/Dsim\Lhrunspecified mutant males are lethal.

    Df(2L)EP372M201/Dsim\Lhrunspecified mutant males are lethal.

    Df(2L)EP372M203/Dsim\Lhrunspecified mutant males are lethal.

    Nup160EP372M69/Dsim\Lhrunspecified mutant males are lethal.

    Df(2L)EP372M219/Dsim\Lhrunspecified mutant males are lethal.

    Nup160EP372M18/Dsim\Lhrunspecified mutant males are lethal.

    Nup160EP372M25/Dsim\Lhrunspecified mutant males are lethal.

    Nup160EP372M54/Dsim\Lhrunspecified mutant males are lethal.

    Nup160EP372M55/Dsim\Lhrunspecified mutant males are lethal.

    Nup160EP372M64/Dsim\Lhrunspecified mutant males are lethal.

    Nup160EP372M121/Dsim\Lhrunspecified mutant males are lethal.

    Nup160EP372M85/Dsim\Lhrunspecified mutant males are lethal.

    Nup160EP372M161/Dsim\Lhrunspecified mutant males are viable.

    Nup160EP372M26/Dsim\Lhrunspecified mutant males are viable.

    Nup160EP372M39/Dsim\Lhrunspecified mutant males are viable.

    Nup160EP372M94/Dsim\Lhrunspecified mutant males are viable.

    Nup160EP372M185/Dsim\Lhrunspecified mutant males are viable.

    Nup160EP372M215/Dsim\Lhrunspecified mutant males are viable.

    Nup160EP372M227/Dsim\Lhrunspecified mutant males are viable.

    Nup160EP372M133/Dsim\Lhrunspecified mutant males are viable.

    Nup160EP372M142/Dsim\Lhrunspecified mutant males are viable.

    Dsim\Int(2L)S, Dsim\Int(2L)D/Dsim\Lhrunspecified mutant males are lethal at the early pupal stage.

    In the progeny of hybrids between Drosophila melanogaster females carrying Dsim\Int(2L)D and Drosophila simulans males homozygous for Dsim\Lhrunspecified, Dsim\Int(2L)D has an effect on male fertility but it does not decrease viability or female fertility.

    In the progeny of hybrids between Drosophila melanogaster females carrying Dsim\Int(2L)S and Drosophila simulans males homozygous for Dsim\Lhrunspecified, Dsim\Int(2L)S is dominant lethal in males.

    In the progeny of hybrids between Drosophila melanogaster females heterozygous for Df(2L)FCK-20 and Drosophila simulans males homozygous for Dsim\Lhrunspecified, Df(2L)FCK-20 is dominant lethal in males.

    In the progeny of hybrids between Drosophila melanogaster females heterozygous for Df(2L)BSC241 and Drosophila simulans males homozygous for Dsim\Lhrunspecified, Df(2L)BSC241 is dominant lethal in males.

    In the progeny of hybrids between Drosophila melanogaster females heterozygous for Df(2L)BSC36 and Drosophila simulans males homozygous for Dsim\Lhrunspecified, Df(2L)BSC36 is dominant lethal in males.

    In the progeny of hybrids between Drosophila melanogaster females heterozygous for Df(2L)Exel6027 and Drosophila simulans males homozygous for Dsim\Lhrunspecified, Df(2L)Exel6027 is dominant lethal in males.

    In the progeny of hybrids between Drosophila melanogaster females heterozygous for Df(2L)ab-c1 and Drosophila simulans males homozygous for Dsim\Lhrunspecified, Df(2L)ab-c1 is dominant lethal in males.

    In the progeny of hybrids between Drosophila melanogaster females heterozygous for Df(2L)BSC242 and Drosophila simulans males homozygous for Dsim\Lhrunspecified, Df(2L)BSC242 is dominant lethal in males.

    In the progeny of hybrids between Drosophila melanogaster females heterozygous for Df(2L)BSC343 and Drosophila simulans males homozygous for Dsim\Lhrunspecified, Df(2L)BSC343 is viable in both males and females.

    In the progeny of hybrids between Drosophila melanogaster females heterozygous for Df(2L)Exel6028 and Drosophila simulans males homozygous for Dsim\Lhrunspecified, Df(2L)Exel6028 is viable in both males and females.

    In the progeny of hybrids between Drosophila melanogaster females heterozygous for Nup160EP372 and Drosophila simulans males homozygous for Dsim\Lhrunspecified, Nup160EP372 is viable in both males and females.

    In the progeny of hybrids between Drosophila melanogaster females heterozygous for Nup160SH2055 and Drosophila simulans males homozygous for Dsim\Lhrunspecified, Nup160SH2055 is viable in both males and females.

    In the progeny of hybrids between Drosophila melanogaster females heterozygous for PBac{RB}RfC38e00704 and Drosophila simulans males homozygous for Dsim\Lhrunspecified, PBac{RB}RfC38e00704 is dominant lethal in males.

    The ability of Dsim\Lhrunspecified to rescue the hybrid lethality of males derived from a cross of D.melanogaster females to D.simulans males is enhanced if the D.melanogaster females carry one copy of Df(3R)e1025-14, Df(3R)3-4 or Df(3R)kar-Sz12, and is suppressed if the D.melanogaster females carry one copy of Df(2R)AA21.

    The D.simulans derived polytene X chromosome has a bloated and diffuse appearance in the male hybrid progeny of a cross between attached X D.melanogaster females and Dsim\Lhrunspecified D.simulans males.

    X[[mel]]/X[[sim]]; trahs.PM hybrids are recovered in crosses of D. melanogaster females to D. simulans males. X[[mel]]/Y[[sim]]; trahs.PM hybrids are not recovered in these crosses. X[[mel]]/Y[[sim]]; trahs.PM phenotypically female hybrids are recovered if the D. simulans male parent is carrying Dsim\Lhrunspecified.

    Complementation and Rescue Data
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    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (3)
    Reported As
    Symbol Synonym
    Dsim\Lhrunspecified
    Name Synonyms
    Secondary FlyBase IDs
      References (13)