FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Aberration: Dmel\Df(2L)FCK-20
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General Information
Symbol
Df(2L)FCK-20
Species
D. melanogaster
Name
FlyBase ID
FBab0028902
Feature type
chromosomal_deletion
Computed Breakpoints include
Features within 32D1--32F3
Sequence coordinates
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
Progenitor
Mutagen
X ray
(Barrio et al., 1999)
Class of aberration (relative to wild type)
chromosomal_deletion
(FlyBase, 2007)
Class of aberration (relative to progenitor)
chromosomal_deletion
(Barrio et al., 1999)
Breakpoints

32D1;32F1-32F3

(Barrio et al., 1999)
Causes alleles
salmFCK-20
(Barrio et al., 1999)
salrFCK-20
(Barrio et al., 1999)
Carries alleles
Transposon Insertions
Formalized genetic data
Genetic mapping information
Comments
Comments on Cytology
Sequence Crossreferences
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted
ab
(Li et al., 2004)
l(2)gd1
(Gallagher and Knoblich, 2006, Jaekel and Klein, 2006)
salm
(Barrio et al., 1999)
salr
(Barrio et al., 1999)
Partially deleted / disrupted
Molecular Data
Completely deleted
Partially deleted
Genes NOT Deleted / Disrupted
Complementation Data
 
Molecular Data
 
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Affected Genes Inferred by Location (0)
    If no genes are listed here, it may be because the affected region is very large. The JBrowse insert above may show an error for the same reason, and other FlyBase tools such as CytoSearch may also fail for large regions. You can contact FlyBase for more help.
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    Phenotypic Data
    In combination with other aberrations

    Df(2L)FCK-20/Dsim\Int(2L)S, Dsim\Int(2L)D females are sterile.

    (Sawamura et al., 2010)

    Lethal in combination with Df(2L)k07716-V.1. Df(2L)FCK-20/Df(2L)k07716-V.1 animals die at the pupal stage and no adult escapers are seen. The mutant pharate adults have rough eyes, scalloped wings and bristles are shorter than normal or missing. Wings discs of mutant third instar larvae show high levels of apoptosis compared to control discs. Mitotic neuroblasts from Df(2L)FCK-20/Df(2L)k07716-V.1 larval brains show a high frequency of telomere fusions and chromosome breaks. Single telomeric associations (in which a single telomere fuses with either its sister telomere or a single non-sister telomere) and double telomere associations are seen. Metaphases with rearranged chromosomes and hyperploid/polyploid cells are seen. Chromosome breaks involving either one or both sister chromatids are seen. Df(2L)FCK-20/Df(2L)k07716-V.1 mutant cells are at least one order of magnitude more sensitive than wild-type cells to the induction of chromosome breaks by irradiation.

    (Ciapponi et al., 2004)
    NOT in combination with other aberrations

    In hybrids with Dsim, Df(2L)FCK-20/Dsim[+] is lethal in males.

    (Tang and Presgraves, 2009)

    Df(2L)FCK-20/+ third instar larvae show an increased number of ddaE dendritic ends compared to wild-type larvae. Df(2L)FCK-20/+ larvae also show an increased number of dendritic ends in vpda neurons.

    (Li et al., 2004)

    The Df(2L)FCK-20 chromosome does not act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{wvar}KR3-2", a stable "brown-red" variant of the P{3'WP-2,wvar}2Lt insertion).

    (Mason et al., 2004)

    Homozygotes die as embryos.

    (Barrio et al., 1999)
    Stocks (2)
    Notes on Origin
    Discoverer
     
    Balancer / Genotype Variants of the Aberration
     
    Separable Components
     
    Other Comments
     

    FlyBase curator comment: The combination Df(2L)FCK-20/Df(2L)k07716-V.1 is referred to as "mre11DC".

    (Ciapponi et al., 2006)
    Synonyms and Secondary IDs (2)
    References (17)