FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ConMhc.PN
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General Information
Symbol
Dmel\ConMhc.PN
Species
D. melanogaster
Name
Myosin heavy chain promoter construct of Nose
FlyBase ID
FBal0060753
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Progenitor genotype
Carried in construct
Cytology
Description

2.5kb fragment of Mhc promoter, containing 456bp upstream of the start of transcription, the entire 5' untranslated region in the first and second exon and the first intron, drives expression of a 3.0kb SmaI-EcoRV fragment of Con cDNA containing the entire open reading frame and the SV40 polyadenylation site.

Allele components
Component
Use(s)
Regulatory region(s)
Encoded product / tool
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

SNa motoneurons often inappropriately innervate a neighbouring non-target muscle, muscle 12. This is not accompanied by a denervation of muscles normally innervated by SNa suggesting the ectopic branching is likely to be formed by collateral sprouting of SNa axons. Ectopic innervation of muscle 12 is only rarely observed in a ConFvex238 genetic background, innervation of the native SNa target muscles is normal. Mutants also exhibit an increase in muscle adhesion in certain pairs of ventral muscle fibres. Concomitant with the increase in muscle adhesion there are abnormalities in muscle innervation. Muscles are normally innervated by the SNb motoneurons on their internal surface, mutants often exhibit muscles innervated on their external surface and only rarely on the internal surface. Innervation defect is due to a specific effect of Con, not an indirect influence of increased muscle adhesion.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
ConMhc.PN
Name Synonyms
Myosin heavy chain promoter construct of Nose
Secondary FlyBase IDs
    References (1)