FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\crc929
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General Information
Symbol
Dmel\crc929
Species
D. melanogaster
Name
FlyBase ID
FBal0060812
Feature type
allele
Associated gene
Dmel\crc
Associated Insertion(s)
P{GawB}crc929
Carried in Construct
Also Known As
C929-GAL4, dimm-GAL4, C929, P{GawB}crc929, c929GAL4, c929G4
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Hewes et al., 2003, Hewes et al., 2000, Hewes et al., 1997, Schaefer and Taghert, 1995)
Progenitor genotype
Associated Insertion(s)
P{GawB}crc929
Cytology
Description

The P{GawB}crc929 insertion is within an intron of crc, and complementation analysis indicates that crc function is disrupted by the insertion, producing a hypomorphic allele (see also FBrf0129856). However, the P{GawB} enhancer trap in P{GawB}crc929 does not reflect expression of crc, but instead reflects expression of the dimm gene, a transcription unit that is proximal to the insertion site. Complementation analysis indicates that dimm function is not affected by the insertion.

(Hewes et al., 2003)

P{GawB} insertion in an intron, upstream of the putative crc-b/c transcriptional start site.

(Hewes et al., 2000)
Allele components
Component
Use(s)
Inserted element
P{GawB}
Encoded product / tool
GAL4
Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Hemizygous lethal phase is primarily after pupariation. Larvae with multiple mouthparts are not seen and puparia are normal in size and shape. Gas bubble translocation, expulsion of the larval tracheae and mouthparts and head eversion are all completed successfully. The distal portion of the everted leg discs often darken abnormally and do not differentiate further. After pupation, the abdomen shrinks markedly and withdraws to a dorsal position in these animals. Subsequently, the head collapses partially or completely into the thoracic cavity. Despite this "head/abdomen-collapsed" phenotype, many pupae develop eye pigmentation and other signs of adult differentiation. crc929 shows the "head/abdomen-collapsed" phenotype when heterozygous over some second chromosome balancers, suggesting haploinsufficiency for crc in some genetic backgrounds.

      (Hewes et al., 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Complements

      crc1

      (Hewes et al., 2000)
      Fails to complement

      crcR6

      (Hewes et al., 2000)
      Rescued by

      crc929 is rescued by Scer\GAL4dimm-929/crcUAS.cHa

      (Hewes et al., 2000)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Precise excision of the P{GawB}crc929 insertion reverts the lethality of the chromosome.

      (Hewes et al., 2000)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      929
      (Hewes et al., 2000)
      ATF-4929
      (Hewes et al., 1997, Schaefer and Taghert, 1995)
      crc929
      Name Synonyms
      Secondary FlyBase IDs
        References (5)