FB2026_02 , released June 18, 2026
Allele: Dmel\Itpr1
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General Information
Symbol
Dmel\Itpr1
Species
D. melanogaster
Name
FlyBase ID
FBal0061794
Feature type
allele
Associated gene
Dmel\Itpr
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(Acharya et al., 1997)
Progenitor genotype
Itprj5B4
(Acharya et al., 1997)
Cytology
Description

Imprecise excision of the P{lacW} element present in Itp-r83Aj5B4, resulting in a 4.8kb deletion from the site of the P{lacW} insertion to +139bp in the Itp-r83A transcription unit.

(Acharya et al., 1997)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3R:5,522,819..5,527,619 [+]
Comment:

Imprecise excision of the P{lacW} element present in Itprj5B4, resulting in a 4.8kb deletion from the site of the P{lacW} insertion to +139bp in the Itpr transcription unit. Position of mutation on reference sequence inferred by FlyBase curator. Endpoints of deletion are approximate.

(Acharya et al., 1997)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Body Wall Contractions (BWCs) in mutants are completely normal. Visceral muscle function as assayed by ingestion is also normal.

      (Sullivan et al., 2000)

      Homozygous larvae hatch normally and initially show healthy behaviour. However they fail to grow beyond the second larval instar stage and never metamorphose, although they live for longer than 7 days as larvae. Brain neuroblasts and midgut progenitor cells are present in 4 day old homozygous larvae, but they do not undergo any significant proliferation. The salivary glands and principal midgut epithelial cells undergo little endoreplication of DNA. Imaginal discs are rudimentary, with little if any cell proliferation or differentiation. Homozygous germ line clones do not produce any viable eggs or embryos. Ommatidia in homozygous clones in the eye show retinal degeneration. Light-induced photoreceptor activity in mutant photoreceptor cells in these clones is indistinguishable from wild-type in terms of sensitivity, kinetics of activation and deactivation, and adaptation.

      (Acharya et al., 1997)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Itpr1 is rescued by Itpr+tCosmidA

      (Acharya et al., 1997)

      Itpr1 is rescued by Itpr+t20

      (Acharya et al., 1997)
      Not rescued by

      Itpr1 is not rescued by ItprtCosmidC

      (Acharya et al., 1997)

      Itpr1 is not rescued by ItprtCosmidB

      (Acharya et al., 1997)

      Itpr1 is not rescued by Itprt6

      (Acharya et al., 1997)
      Comments

      Lethality is rescued by Itp-r83A+tCosmidA and Itp-r83A+t20 but not by Itp-r83AtCosmidB, Itp-r83AtCosmidC or Itp-r83At6.

      (Acharya et al., 1997)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Itp-r83A1
      Itp-r1
      (Sullivan et al., 2000)
      Itpr1
      Name Synonyms
      Secondary FlyBase IDs
        References (2)