FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\E(spl)m8-HLH1,stop.UAS
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General Information
Symbol
Dmel\E(spl)m8-HLH1,stop.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0063459
Feature type
allele
Associated gene
Dmel\E(spl)m8-HLH
Associated Insertion(s)
Carried in Construct
P{UAS-E(spl)m8-HLH1,stop}
Key Links
Transgenic product class
dominant_negative_variant
(Giebel and Campos-Ortega, 1997)
inframe_deletion
(Giebel and Campos-Ortega, 1997)
Mutagen
Nature of the Allele
Transgenic product class
dominant_negative_variant
(Giebel and Campos-Ortega, 1997)
inframe_deletion
(Giebel and Campos-Ortega, 1997)
Mutagen
in vitro construct
(Giebel and Campos-Ortega, 1997)
Progenitor genotype
Carried in construct
P{UAS-E(spl)m8-HLH1,stop}
Cytology
Description

UASt regulatory sequences drive expression of a cDNA fragment which encodes E(spl)m8-HLH that is truncated at the position at which the deletion occurs in E(spl)m8-HLH1 (this results in a protein that lacks the C-terminal 56 amino acid residues). The encoded protein acts as a dominant negative (as assayed by effects on bristle development).

(Giebel and Campos-Ortega, 1997)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
E(spl)m8-HLH
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      adult abdomen & macrochaeta, with Scer\GAL4sca-537.4

      (Giebel and Campos-Ortega, 1997)

      adult head & macrochaeta, with Scer\GAL4sca-537.4

      (Giebel and Campos-Ortega, 1997)

      scutum & macrochaeta & adult, with Scer\GAL4sca-537.4

      (Giebel and Campos-Ortega, 1997)
      Detailed Description
      Statement
      Reference

      Scer\GAL4sca-537.4-mediated expression enhances development of bristles on the notum and causes development of split bristles on the abdomen and head.

      (Giebel and Campos-Ortega, 1997)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Strong increase in the number of ectopic scutellar macrochaetes of strain ZB1.4 (activator insertion Scer\GAL4455.2 is combined with l(1)scScer\UAS.cHa).

      (Giebel and Campos-Ortega, 1997)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      E(spl)1,stop.Scer\UAS
      E(spl)1,stop.UAS
      E(spl)m8-HLH1,stop.Scer\UAS
      E(spl)m8-HLH1,stop.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)