FlyBase Allele Report: Dmel\dia[k07135]

General Information

Symbol

Dmel\dia^k07135

Species

D. melanogaster

Name

FlyBase ID

FBal0064403

Feature type

allele

Associated gene

Dmel\dia

Associated Insertion(s)

P{lacW}dia^k07135

Carried in Construct

Also Known As

l(2)k07135

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Butler et al., 2001, Spradling et al., 1999, BDGP Project Members, 1994-1999)

Progenitor genotype

Associated Insertion(s)

P{lacW}dia^k07135

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2L:20,758,422..20,758,422 [-]

(Butler et al., 2001, Spradling et al., 1999, BDGP Project Members, 1994-1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Phenotype Manifest In

furrow canal | embryonic stage 4 | maternal effect

(Webb et al., 2009)

Detailed Description

Statement

Reference

The offspring of heterozygous dia^k07135 mothers exhibit obvious actin pseudocleavage furrow extension defects at 1.6 and 2.2 micrometers from the embryo surface.

(Webb et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

dia[+]/dia^k07135 is a suppressor of visible phenotype of Rok^cat.GMR

(Verdier et al., 2006)

dia[+]/dia^k07135 is a suppressor of visible phenotype of LIMK1^UAS.cCa, Scer\GAL4^en-e16E

(Chen et al., 2004)

Phenotype Manifest In

Enhanced by

Statement

Reference

dia^k07135 has cortical actin cytoskeleton | embryonic stage 4 | maternal effect phenotype, enhanceable by Apc2^g10/Apc2[+]

(Webb et al., 2009)

Enhancer of

Statement

Reference

dia[+]/dia^k07135 is an enhancer of cortical actin cytoskeleton | embryonic stage 4 | maternal effect phenotype of Apc2^g10

(Webb et al., 2009)

Suppressor of

Statement

Reference

dia[+]/dia^k07135 is a suppressor of eye phenotype of Rok^cat.GMR

(Verdier et al., 2006)

dia[+]/dia^k07135 is a suppressor of crossvein phenotype of Rok^cat.UAS.cVa, Scer\GAL4^en-e16E

(Verdier et al., 2006)

dia[+]/dia^k07135 is a suppressor of wing phenotype of LIMK1^UAS.cCa, Scer\GAL4^en-e16E

(Chen et al., 2004)

Additional Comments

Genetic Interactions

Statement

Reference

Embryos in the offspring of dia^k07135/+ ; Apc2^g10 mothers have increased metaphase cap-like actin at the apical surface as compared to single heterozygous controls. The number of incomplete rings is significantly increased in these embryos.

(Webb et al., 2009)

The lack of crossveins in wings from animals expressing rok^cat.Scer\UAS under the control of Scer\GAL4^en-e16E is not suppressed in a hts⁰¹¹⁰³/+ background, but is suppressed in a dia^k07135/+ background.

(Verdier et al., 2006)

dia^k07135/+ suppresses the mutant wing phenotype caused by expression of LIMK1^Scer\UAS.cCa under the control of Scer\GAL4^en-e16E (the % of wings with normal morphology at 18^oC is increased from 9% to 97%).

(Chen et al., 2004)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

dia³⁸

(Butler, 2001)

dia^k07140

(BDGP Project Members, 1994-1999)

Comments

Images (0)