FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\l(2)k04308k04308
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General Information
Symbol
Dmel\l(2)k04308k04308
Species
D. melanogaster
Name
FlyBase ID
FBal0064538
Feature type
allele
Associated gene
l(2)k04308
Associated Insertion(s)
P{lacW}gemk04308
Carried in Construct
Also Known As
l(2)k04308
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(BDGP Project Members, 1994-1999)
Progenitor genotype
Associated Insertion(s)
P{lacW}gemk04308
Cytology
Description
Allele components
Component
Use(s)
Inserted element
P{lacW}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  autosomal dominant cerebellar ataxia
      modeled by Hsap\ATXN8OSCTG112.UAS
      (Mutsuddi et al., 2004)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The average number of crystal cells per embryo is reduced (to 12.3) in homozygous stage 13-14 embryos compared to wild type (36 +/- 2.2 cells on average).

      (Milchanowski et al., 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      l(2)k04308k04308/l(2)k04308[+] is a suppressor of abnormal neuroanatomy phenotype of Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF

      (Mutsuddi et al., 2004)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer

      I. Kiss.

      (BDGP Project Members, 1994-1999)

      Deficiency complementation analysis is consistent with the lethality of the line being associated with the insertion. The insertion maps within the gem transcription unit. However, since the insertion lies within a gene-rich region, the lethality can not yet be conclusively mapped to a single gene from these results. Thus l(2)k04308k04308 (representing the lethality of the chromosome) has been kept as a separate allele in FlyBase for now.

      (Kahsai et al., 2016)
      Comments
      Comments

      Complements: CCS03221. Complements: Pfk06339. Complements: 14-3-3ΞΆ07103. Complements: Hr46k01017. Complements: l(2)k03610k03610. Complements: l(2)k03610k03703. Complements: Hr46k10308. Complements: l(2)46Edk16104.

      (BDGP Project Members, 1994-1999)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      P10542
      (Milchanowski et al., 2004)
      l(2)k04308
      (Mutsuddi et al., 2004, Spradling et al., 1999)
      l(2)k04308k04308
      Name Synonyms
      Secondary FlyBase IDs
        References (5)