FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\sws4
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General Information
Symbol
Dmel\sws4
Species
D. melanogaster
Name
FlyBase ID
FBal0065673
Feature type
allele
Associated gene
Dmel\sws
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Amino acid replacement: G956D. Nucleotide substitution: G3357A.

    (Kretzschmar et al., 1997)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    X:7,961,608..7,961,608 [-]
    Nucleotide change:

    G7961608A

    Reported nucleotide change:

    G3357A

    Amino acid change:

    G956D | sws-PA; G956D | sws-PC

    Reported amino acid change:

    G956D

    (Kretzschmar et al., 1997)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 1 )
        Disease
        Evidence
        References
        model of  neurodegenerative disease
        CEA
        (Coleman et al., 2024, Banerjee et al., 2021)
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Homozygous adults show a significant reduction in lifespan compared to wild-type flies.

        (Kretzschmar et al., 1997)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        NOT suppressed by
        Statement
        Reference

        sws4 has partially lethal - majority live phenotype, non-suppressible by iPLA2-VIAΔ23/iPLA2-VIAΔ23

        (Banerjee et al., 2021)
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        Comments
        Comments

        Mosaic analysis suggests a cell-autonomous or short-range function for the sws gene product.

        (Kretzschmar et al., 1997)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        sws4
        (Coleman et al., 2024, Banerjee et al., 2021, Stratoulias and Heino, 2015)
        Name Synonyms
        Secondary FlyBase IDs
          References (4)