FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\iPLA2-VIAΔ23
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General Information
Symbol
Dmel\iPLA2-VIAΔ23
Species
D. melanogaster
Name
FlyBase ID
FBal0369563
Feature type
allele
Associated gene
Dmel\iPLA2-VIA
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Banerjee et al., 2021)
Mutagen
P-element activity
(Banerjee et al., 2021)
Progenitor genotype
P{EPgy2}iPLA2-VIAEY05103
(Banerjee et al., 2021)
Cytology
Description

1.4kb deletion that spans the transcription initiation site and both predicted translation start codons of iPLA2-VIA. Generated by imprecise excision of P{EPgy2}iPLA2-VIAEY05103.

(Banerjee et al., 2021)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  neurodegenerative disease
      CEA
      (Banerjee et al., 2021)
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      model of  neurodegenerative disease
      is ameliorated by iPLA2-VIASA.UAS.PB.Tag:HA
      (Banerjee et al., 2021)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      iPLA2-VIAΔ23 homozygous adults show a progressive decrease in climbing activity.

      In old females, egg chamber germ cells (particularly during mid-oogenesis) show mitochondria aggregation, with reduction in the intricacy of the mitochondrial network. In old females, egg chamber germ cells undergo apoptosis.

      (Banerjee et al., 2021)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Suppressor of
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      iPLA2-VIAΔ23
      (Meimoun et al., 2025)
      iPLA2-VIAΔ23
      (Banerjee et al., 2021)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)