FlyBase Allele Report: Dmel\Rap1[E127]

General Information

Symbol

Dmel\Rap1^E127

Species

D. melanogaster

Name

FlyBase ID

FBal0066000

Feature type

allele

Associated gene

Dmel\Rap1

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Fischer et al., 1997)

Progenitor genotype

Cytology

Description

Amino acid replacement: T58M.

(Li et al., 1997)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3L:1,861,039..1,861,039 [-]

Nucleotide change:

C1861039T

Amino acid change:

T58M | Rap1-PA; T58M | Rap1-PB; T58M | Rap1-PC

Reported amino acid change:

T58M

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Li et al., 1997)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable

(Fischer et al., 1997, Li et al., 1997)

visible | recessive

(Li et al., 1997)

Phenotype Manifest In

eye photoreceptor cell

(Fischer et al., 1997, Li et al., 1997)

photoreceptor cell R7

(Fischer et al., 1997)

Detailed Description

Statement

Reference

Homozygotes exhibit rough eyes, some facets are missing R7 cells and numbers of outer R cells.

(Fischer et al., 1997)

Roughened external eye morphology, internally most facets are missing R7 and some are missing outer cells.

(Li et al., 1997)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

Rap1^E127 has eye photoreceptor cell phenotype, enhanceable by faf^BX3

(Li et al., 1997)

Rap1^E127 has eye photoreceptor cell phenotype, enhanceable by faf^FO8

(Li et al., 1997)

Additional Comments

Genetic Interactions

Statement

Reference

Enhances the faf^BX3/faf^FO8 eye phenotype: facets are often missing the R7 receptor cell.

(Fischer et al., 1997)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Mutation is not a simple hypermorph or hypomorph. The protein does provide some wild type activity and also antagonises the wild-type function in some manner.

(Li et al., 1997)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

E(faf)E127

(Li et al., 1997)

R^E127

Rap1^E127

Rap1^T58M

(Li et al., 1997)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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